Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLYMPHATIC SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GLYMPHATIC SYSTEM |
| Summary | # [Glymphatic System](/entities/glymphatic-system)[/entities/glymphatic-system](/entities/glymphatic-system) ## Overview [Glymphatic System](/entities/glymphatic-system)[/entities/glymphatic-system |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
GLYMPHATIC_SYSTEM["GLYMPHATIC SYSTEM"]
GLYMPHATIC_SYSTEM -->|"mediates"| Brain_Interstitial_Solute_Clea["Brain Interstitial Solute Clearance"]
GLYMPHATIC_SYSTEM -->|"involved_in"| NEURODEGENERATION["NEURODEGENERATION"]
GLYMPHATIC_SYSTEM -->|"involved_in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
AQP4["AQP4"] -->|"involved_in"| GLYMPHATIC_SYSTEM
Aquaporin_4["Aquaporin-4"] -->|"participates in"| GLYMPHATIC_SYSTEM| Target | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | involved_in | entity | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AQP4 | involved_in | entity | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Glymphatic System-Enhanced Antibody Clearance Reversal | 0.537 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Characteristics of MRI lesions in AQP4 antibody-positive NMOSD, MOGAD, and multi [PMID:40773034] | Leitner U, Chew SH, Blanch J, Viswanatha | J Neurol | 2025 | 1 |
| B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum [PMID:39222408] | Bennett JL, Pittock SJ, Paul F, Kim HJ, | Ann Clin Transl Neurol | 2024 | 1 |
| Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic str [PMID:34530847] | Carnero Contentti E, Correale J | J Neuroinflammation | 2021 | 1 |
| Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neur [PMID:41881459] | Filippatou AG, Gakis G, Bacchetti A, Kim | Neurology(R) neuroimmunology & | 2026 | 0 |
| β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral ed [PMID:41535708] | Yu MJ, Xiong RQ, Wu JW, Li YC, Xie JX et | Acta Pharmacol Sin | 2026 | 0 |
| CCR2 knockdown attenuates post-hemorrhagic hydrocephalus and improves glymphatic [PMID:41539459] | Deng H, Zhang S, Wang H, Liu X, Zhong K | Exp Neurol | 2026 | 0 |
| Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt [PMID:41665955] | Qi F, Lennon VA, Zhao S, Guo Y, Ding H e | J Clin Invest | 2026 | 0 |
| Safety and efficacy of ravulizumab in patients with NMOSD previously treated wit [PMID:41782198] | Bennett JL, Bhattacharyya S, Zabeti A, L | Mult Scler | 2026 | 0 |
| NMOSD and MOGAD: Updates on diagnostic criteria. [PMID:41927386] | Marignier R, Leal Rato M | Rev Neurol (Paris) | 2026 | 0 |
| Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387] | Elosua-Bayés I, Cobo-Calvo A | Rev Neurol (Paris) | 2026 | 0 |
| Psychiatric comorbidities cluster early after onset in MOGAD: a cross-sectional [PMID:41956817] | Niederschweiberer M, Bakir C, Vorasoot N | J Neurol Neurosurg Psychiatry | 2026 | 0 |
| Astrocyte-related proteins mediate the association of YWHAG with Alzheimer's pat [PMID:41957344] | Zhang Z, Huang P, Yang Y, Wu H, Yao X et | Transl Psychiatry | 2026 | 0 |
| Understanding Further the Phenotypic Spectrum of Central Nervous System Inflamma [PMID:41957957] | Gulec B, Everest E, Tutuncu M, Bilge U, | Ann Clin Transl Neurol | 2026 | 0 |
| Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum di [PMID:41915816] | Jiang X, Chen J, Wen Y, Yuan L, Zhang J | The Journal of international m | 2026 | 0 |
| Glymphatic System Dysfunction in Central Nervous System Diseases. [PMID:41792880] | Zahran A, Abu-Khazneh O, Bdair M, Hajjeh | CNS neuroscience & therapeutic | 2026 | 0 |
| Diagnostic Value of the Kappa Free Light Chain Index to Distinguish MOGAD, NMOSD [PMID:41921124] | Tournier A, Gavoille A, Pique J, Levraut | Neurology | 2026 | 0 |
| Mapping the Brain's Glymphatic System. [PMID:41751308] | Voumvourakis K, Thomaidis NS, Tsiodras S | Biomedicines | 2026 | 0 |
| Frequency of AQP4 and MOG Antibodies in Patients With Optic Neuritis Fulfilling [PMID:41843863] | Deschamps R, Papeix C, Demortiere S, Lar | Neurology | 2026 | 0 |
| A compound pulsed magnetic field achieves superior cognitive benefits against Al [PMID:41856031] | Wang X, Wang X, Zhao H, Zhao C, Wang P, | Neurotherapeutics : the journa | 2026 | 0 |
| Physical exercise as a non-pharmacological strategy to enhance glymphatic functi [PMID:41676384] | Ghayourvahdat A, Azimizonuzi H, Ahmed M | IBRO neuroscience reports | 2026 | 0 |