concept

SLEEP-WAKE CYCLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLEEP-WAKE CYCLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

234Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SLEEP-WAKE CYCLE is a concept in neurodegeneration research. Key relationships include: regulates, biomarker for, causes. Associated with ALS, Als, Alzheimer. Connected to 59 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SLEEP-WAKE CYCLE
Key Genes/Proteins	ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
Related Diseases	Als, ALS, Alzheimer, Bipolar
Related Pathways	Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sleep-Wake Cycle

mechanism · 3410 words

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Pathway Diagram

graph TD
    SLEEP_WAKE_CYCLE["SLEEP-WAKE CYCLE"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Alzheimer["Alzheimer"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Ms["Ms"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Dementia["Dementia"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Als["Als"]
    SLEEP_WAKE_CYCLE -->|"interacts"| Diabetes["Diabetes"]
    SLEEP_WAKE_CYCLE -->|"interacts"| Obesity["Obesity"]
    SLEEP_WAKE_CYCLE -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    SLEEP_WAKE_CYCLE -->|"regulates"| Inflammation["Inflammation"]
    SLEEP_WAKE_CYCLE -->|"regulates"| ALS["ALS"]
    CIRCADIAN_CLOCK_GENES["CIRCADIAN CLOCK GENES"] -->|"regulates"| SLEEP_WAKE_CYCLE
    Orexin["Orexin"] -->|"regulates"| SLEEP_WAKE_CYCLE
    BMAL1["BMAL1"] -->|"regulates"| SLEEP_WAKE_CYCLE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.biomarker for.-> SLEEP_WAKE_CYCLE
    AMYLOID_BETA["AMYLOID-BETA"] -.biomarker for.-> SLEEP_WAKE_CYCLE
    TAU["TAU"] -.biomarker for.-> SLEEP_WAKE_CYCLE
    CRY["CRY"] -->|"regulates"| SLEEP_WAKE_CYCLE
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| SLEEP_WAKE_CYCLE
    CLOCK["CLOCK"] -->|"regulates"| SLEEP_WAKE_CYCLE

Outgoing (123)

Target	Relation	Type	Str
Glymphatic system	regulates	pathway	0.95
Alzheimer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Diabetes	interacts_with	disease	0.65
Obesity	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
NEURON	regulates	gene	0.60
TAU	regulates	gene	0.60
Sleep-Wake	regulates	pathway	0.60
CLOCK GENES	regulates	gene	0.60
BMAL1	inhibits	gene	0.60
BACE1	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CLOCK	inhibits	gene	0.60
APP	inhibits	gene	0.60
TAU	inhibits	gene	0.60
IBA1	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
Circadian Rhythm	associated_with	pathway	0.60
Tau Phosphorylation	inhibits	pathway	0.60

Incoming (111)

Source	Relation	Type	Str
ORAS	associated_with	disease	0.95
CIRCADIAN CLOCK GENES	regulates	gene	0.95
Circadian Clock Genes	regulates	pathway	0.95
OSAS	associated_with	disease	0.95
Obstructive Sleep Apnea Syndrome	associated_with	disease	0.95
32250301	oscillate with	paper	0.90
Orexin	regulates	protein	0.90
BMAL1	regulates	gene	0.90
OREXIN	regulates	entity	0.90
BMAL1	regulates	entity	0.90
Obstructive Sleep Apnea Syndrome	disrupts	disease	0.90
Chronic Sleep Fragmentation	associated_with	phenotype	0.90
41579208	regulates	paper	0.90
Intermittent Hypoxia	associated_with	mechanism	0.90
PER	regulates	entity	0.85
BMAL1	associated_with	gene	0.85
Serotonin	regulates	compound	0.80
GRM5	regulates	gene	0.70
PER	causes	gene	0.60
CLOCK	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
CLOCK	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CLOCK GENE	biomarker_for	gene	0.60
HCRTR2	associated_with	gene	0.60
HCRTR2	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.60
HCRT	associated_with	gene	0.60
C-FOS	activates	gene	0.60
FOS	activates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
GABA	regulates	gene	0.60
CLOCK GENE	regulates	gene	0.60
GFAP	inhibits	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NR3C1	regulates	gene	0.60
CANCER	regulates	gene	0.60
MMP2	regulates	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
TAU PATHOLOGY	regulates	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Complement Regulator CD55/CD46 Expression Modulates Microgli	0.380	synaptic biology	What determines the selectivity of compl

Mentioning Analyses (1)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Sleep disruption as cause and consequence of neurodegeneration

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Related Research

Hypotheses and analyses mentioning SLEEP-WAKE CYCLE in their description or question text

No additional research found