gene

AQUAPORIN-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AQUAPORIN-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

459Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

AQUAPORIN-4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, causes. Associated with ALS, Aging, Als. Connected to 84 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AQUAPORIN
Full Name	Aquaporin 4
Aliases	AQP4, MIWC, WCH4
Chromosome	18q11.2
Protein Family	Aquaporin (AQP) family
Function	Water channel protein; forms orthogonal arrays in astrocyte endfeet. Critical for brain water homeostasis and glymphatic clearance.
Primary Expression	Astrocyte endfeet, kidney collecting duct, ependymal cells
Subcellular Localization	Astrocyte end-feet, perivascular, ependymal
Molecular Weight	34.8 kDa
Gene Type	Protein-coding
Pathways	Vasopressin-regulated water reabsorption, Glymphatic clearance
UniProt ID	P55064
GeneCards	AQUAPORIN
Human Protein Atlas	AQUAPORIN
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer'S Disease, Autoimmune
Interactions	EMD, CANCER, MAX, CR2, CYTOKINES, PARKINSON
KG Connections	453 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: AQUAPORIN-4 — AlphaFold P55064 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AQUAPORIN_4["AQUAPORIN-4"] -->|"regulates"| Aging["Aging"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| Autoimmune["Autoimmune"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| ALS["ALS"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"activates"| Cancer["Cancer"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"associated"| Multiple_Sclerosis_1["Multiple Sclerosis"]
    AMYLOID["AMYLOID"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    JUN["JUN"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    AQP4["AQP4"] -->|"associated"| AQUAPORIN_4["AQUAPORIN-4"]
    style AQUAPORIN_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (335)

Target	Relation	Type	Str
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.80
Aging	regulates	disease	0.65
Autoimmune	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Autoimmune	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Als	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Als	activates	disease	0.65
Lymphoma	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Sepsis	associated_with	disease	0.65
Aging	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Diabetes	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65

Incoming (124)

Source	Relation	Type	Str
AMYLOID	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
JUN	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
COMPLEMENT	causes	gene	0.60
AQP4	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
AQP4	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
OLIGODENDROCYTE	biomarker_for	gene	0.60
MOG	biomarker_for	gene	0.60
EMD	activates	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ASTROCYTES	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PROINFLAMMATORY CYTOKINES	associated_with	gene	0.60
OLIGODENDROCYTE	causes	gene	0.60
ASTROCYTE	regulates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
AND	regulates	gene	0.60
AQP4	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
AVP	regulates	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
HIF-1Α	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
PPAR-Γ	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AQP4	treats	entity	0.60
AQP4	activates	entity	0.60
PARKINSON	inhibits	gene	0.60
ATP	regulates	gene	0.60
MMP9	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
ABCB1	regulates	gene	0.60
AQP4	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ATM	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Driven Aquaporin-4 Dysregulation	0.590	neurodegeneration	Senolytic therapy for age-related neurod
Aquaporin-4 Polarization Rescue	0.507	neurodegeneration	4R-tau strain-specific spreading pattern
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu	0.437	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

neurodegeneration | 2026-04-07 | 0 hypotheses

How can AQP4 be effectively targeted therapeutically to improve neurological out

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Aquaporin-4 in glymphatic system, and its implication for central nervous system [PMID:36796590]	Peng S, Liu J, Liang C, Yang L, Wang G	Neurobiol Dis	2023	2
Uncommon inflammatory/immune-related myelopathies. [PMID:34715593]	Valencia-Sanchez C, Flanagan EP	J Neuroimmunol	2021	2
Novel function of TREK-1 in regulating adipocyte differentiation and lipid accum [PMID:40057491]	Kim A, Jung S, Kim Y, Jung J, Lee S, Lee	Cell Death Dis	2025	1
Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978]	Redmon SN, Yarishkin O, Rudzitis CN, Lak	Invest Ophthalmol Vis Sci	2025	1
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. [PMID:38383779]	Afzali AM, Nirschl L, Sie C, Pfaller M,	Nature	2024	1
Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A- [PMID:36410022]	Zyrianova T, Lopez B, Zou K, Gu C, Pham	Am J Physiol Lung Cell Mol Phy	2023	1
Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressu [PMID:31959516]	Reeves BC, Karimy JK, Kundishora AJ, Mes	Trends Mol Med	2020	1
Inebilizumab-cdon. [PMID:32936251]	Unknown	American journal of health-sys	2020	1
The glymphatic pathway in neurological disorders. [PMID:30353860]	Rasmussen MK, Mestre H, Nedergaard M	Lancet Neurol	2018	1
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci f [PMID:30061609]	Wyss AB, Sofer T, Lee MK, Terzikhan N, N	Nat Commun	2018	1
Temperature sensitivity of two-pore (K2P) potassium channels. [PMID:25366235]	Schneider ER, Anderson EO, Gracheva EO,	Curr Top Membr	2014	1
TREK-king the blood-brain-barrier. [PMID:24557892]	Bittner S, Ruck T, Fernández-Orth J, Meu	J Neuroimmune Pharmacol	2014	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral ed [PMID:41535708]	Yu MJ, Xiong RQ, Wu JW, Li YC, Xie JX et	Acta Pharmacol Sin	2026	0
Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt [PMID:41665955]	Qi F, Lennon VA, Zhao S, Guo Y, Ding H e	J Clin Invest	2026	0
Safety and efficacy of ravulizumab in patients with NMOSD previously treated wit [PMID:41782198]	Bennett JL, Bhattacharyya S, Zabeti A, L	Mult Scler	2026	0
Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387]	Elosua-Bayés I, Cobo-Calvo A	Rev Neurol (Paris)	2026	0
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462]	Tan Y, Ye H, Ge Q, Wang P, Liu Z et al.	J Magn Reson Imaging	2026	0
Psychiatric comorbidities cluster early after onset in MOGAD: a cross-sectional [PMID:41956817]	Niederschweiberer M, Bakir C, Vorasoot N	J Neurol Neurosurg Psychiatry	2026	0
Astrocyte-related proteins mediate the association of YWHAG with Alzheimer's pat [PMID:41957344]	Zhang Z, Huang P, Yang Y, Wu H, Yao X et	Transl Psychiatry	2026	0

AQUAPORIN-4

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

calcium-dysregulation-comparison

Microglial Cells — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

Blood-Brain Barrier Dysfunction in Neurodegeneration

Vascular Cognitive Impairment (VCI)

blood-brain-barrier

cognitive-reserve-cbs-psp

Traumatic Brain Injury and Neurodegeneration Pathway

Glia-Neuron Crosstalk in Alzheimer's Disease

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Astrocytes

neurovascular-coupling

Multiple Sclerosis (MS)

neurovascular-dysfunction

Sleep and Neurodegeneration

Sleep Dysfunction in Neurodegeneration