concept

LYSOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

2Hypotheses

3Analyses

19Outgoing

25Incoming

0Experiments

3Debates

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💡 Concept Info

Name	LYSOSOMES
Key Genes/Proteins	C9ORF72

Pathway Diagram

graph TD
    LYSOSOMES["LYSOSOMES"]
    LYSOSOMES -->|"regulates"| Autophagy["Autophagy"]
    LYSOSOMES -->|"involved_in"| Endocytosis["Endocytosis"]
    LYSOSOMES -->|"involved_in"| Lysosomal_Storage_Disorders["Lysosomal Storage Disorders"]
    LYSOSOMES -->|"causes"| Lysosomal_Storage_Diseases["Lysosomal Storage Diseases"]
    LYSOSOMES -->|"causes"| Neurodegeneration["Neurodegeneration"]
    LYSOSOMES -->|"involved_in"| Amyloid_Beta["Amyloid Beta"]
    LYSOSOMES -->|"involved_in"| Nutrient_Sensing["Nutrient Sensing"]
    TMEM192["TMEM192"] -->|"expressed in"| LYSOSOMES
    Autophagy -->|"involved_in"| LYSOSOMES
    Endocytosis -->|"involved_in"| LYSOSOMES
    Lysosome_Quality_Control["Lysosome Quality Control"] -->|"regulates"| LYSOSOMES
    Autophagosomes["Autophagosomes"] -->|"interacts"| LYSOSOMES
    Phosphatidylinositol_3_Phospha["Phosphatidylinositol 3-Phosphate"] -->|"regulates"| LYSOSOMES
    Lysosome_Membrane_Protein_Regu["Lysosome Membrane Protein Regulation"] -->|"regulates"| LYSOSOMES
    Lysosome_Membrane_Protein_Degr["Lysosome Membrane Protein Degradation"] -->|"involved_in"| LYSOSOMES

Outgoing (19)

Target	Relation	Type	Str
Endocytosis	involved_in	process	0.95
Autophagy	involved_in	process	0.95
Autophagy	regulates	process	0.95
Lysosomal Storage Diseases	causes	disease	0.90
Cancer	associated_with	disease	0.90
Lysosomal Storage Disorders	involved_in	disease	0.90
Neurodegeneration	causes	disease	0.90
Neurodegeneration	associated_with	disease	0.90
Autophagy	mediates	process	0.90
Hematoma clearance	involved_in	process	0.90
Parkinson'S Disease	involved_in	disease	0.88
Amyloid Beta	involved_in	protein	0.85
Ferroptosis	regulates	process	0.85
Nutrient Sensing	involved_in	process	0.85
Phagosome	interacts_with	cell_type	0.85
Signal Transduction	involved_in	process	0.85
DAT	degrades	protein	0.80
autophagy	regulates	process	0.70
distal_axons	limited_trafficking_to	mechanism	0.50

Incoming (25)

Source	Relation	Type	Str
Glycerophosphodiesters	associated_with	compound	0.95
Lysosome Quality Control	regulates	pathway	0.95
Tagless Lysoip	targets	process	0.95
TMEM192	expressed_in	protein	0.95
tetrandrine	targets	compound	0.95
SQSTM1	transports	protein	0.95
LAMP1	component_of	protein	0.95
Lipotoxicity	targets	process	0.95
Endocytosis	involved_in	process	0.95
Autophagy	associated_with	process	0.95
32416272	responsible for eliminating	paper	0.90
Mdv Cargoes	transports	protein	0.90
CLN3 Disease	associated_with	disease	0.90
Autophagosomes	interacts_with	organelle	0.90
28028177	is degraded in	paper	0.90
Peripheral Blood Mononuclear Cells	expressed_in	cell_type	0.85
Phosphatidylinositol 3-Phosphate	regulates	compound	0.85
Autophagosomes	associated_with	mechanism	0.85
Lysosome Membrane Protein Degradation	involved_in	process	0.80
Lysosome Membrane Protein Regulation	regulates	process	0.80
Induced Pluripotent Stem Cell-Derived Neurons	expressed_in	cell_type	0.80
ATM	expressed_in	protein	0.70
Hsp70	regulates	protein	0.70
autophanosomes	associated_with	process	0.70
C9ORF72	regulates	gene	0.64

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Autophagy Activation ULK1/VPS34 (H3): Lipid Routing to Lysos	0.600	neurodegeneration	Does restoring neuronal AMPK activity re
PI3P Generation at Damaged Lysosomes Promotes Membrane Repai	0.530	neurodegeneration	How does controlled lysosomal membrane p