protein

FTO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

2Analyses

50Outgoing

21Incoming

0Experiments

4Debates

Summary

Page for FTO Protein (Fat Mass and Obesity-Associated Protein)

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🔬 Protein Info

Gene Symbol	FTO
Aliases	Fat Mass and Obesity-Associated Protein
Function	FTO (Fat Mass and Obesity-Associated Protein), also known as ALKBH9, is a 505-amino acid nuclear and cytoplasmic protein that functions as an N6-methyladenosine (m6A) demethylase.
Subcellular Localization	</strong> Nucleus, cytoplasm</div> <div class="infobox-row"><strong>Protein Fa
Molecular Weight	58.6 kDa
Amino Acids	505 aa
Pathways	autophagy, adipogenesis, IGF1 signaling, Lipid Metabolism, Oxidative Stress
GeneCards	FTO
Human Protein Atlas	FTO
Associated Diseases	Alzheimer's disease, Fat Mass And Obesity, Obesity
Known Drugs/Compounds	FB23, N6-Methyladenosine
Interactions	CERS6, DNA, IGF1, PARP1, RNA, UCP2
KG Connections	84 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

FTO Protein (Fat Mass and Obesity-Associated Protein)

protein · 799 words

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Pathway Diagram

graph TD
    FTO["FTO"]
    ATG5["ATG5"]
    FTO -->|"regulates"| ATG5
    ATG7["ATG7"]
    FTO -->|"regulates"| ATG7
    autophagy(["autophagy"])
    FTO -->|"activates"| autophagy
    adipogenesis(["adipogenesis"])
    FTO -->|"activates"| adipogenesis
    FTO -->|"regulates"| autophagy
    FTO -->|"regulates"| adipogenesis
    style FTO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
N6-Methyladenosine	modulates	compound	0.95
m6A RNA methylation	regulates	process	0.95
Metabolic Disturbances	inhibits	phenotype	0.95
Cognitive Decline	inhibits	phenotype	0.95
CDK2	targets	protein	0.95
m6A modification	modulates	pathway	0.90
Diabetic Retinopathy	contributes_to	disease	0.90
adipogenesis	activates	pathway	0.90
adipogenesis	regulates	pathway	0.90
Post-Stroke Depression	involved_in	disease	0.90
m6A modification	inhibits	process	0.90
autophagy	activates	pathway	0.90
autophagy	regulates	pathway	0.90
ATG5	regulates	protein	0.90
ATG7	regulates	protein	0.90
IGF1 signaling	modulates	pathway	0.85
STAT3	regulates	gene	0.85
Alzheimer's disease	implicated_in	disease	0.80
ALZHEIMER'S DISEASE	modulates	disease	0.80
m6A landscape reshaping	modulates	mechanism	0.70
Fat Mass And Obesity	associated_with	phenotype	0.70
ALS	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Retinopathy	therapeutic_target	disease	0.65
Senescence	expressed_in	disease	0.65
Obesity	associated_with	disease	0.65
senescence	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
CDK2	causes	gene	0.60
YTHDF1	contributes_to	gene	0.60
RNA	contributes_to	gene	0.60
Igf	therapeutic_target	protein	0.60
Ras	associated_with	protein	0.60
Rb	associated_with	protein	0.60
RNA	regulates	gene	0.60
PARP1	inhibits	gene	0.60
PARP1	activates	gene	0.60
PARP1	regulates	gene	0.60
DIABETIC RETINOPATHY	causes	gene	0.60
CANCER	contributes_to	gene	0.60
IGF2BP1	contributes_to	gene	0.60
METTL3	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
WTAP	associated_with	gene	0.60
ALKBH5	associated_with	gene	0.60
UCP2	interacts_with	gene	0.60
INSR	regulates	gene	0.60

Incoming (21)

Source	Relation	Type	Str
FB23	inhibits	drug	0.95
Lactylation	modulates	process	0.90
CDK2	therapeutic_target	gene	0.60
DNA	regulates	gene	0.60
DNA	activates	gene	0.60
DIABETIC RETINOPATHY	causes	gene	0.60
ROS	expressed_in	gene	0.60
MIRNAS	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ATP	expressed_in	gene	0.60
IGF2BP1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
HNRNPA2B1	contributes_to	gene	0.60
WTAP	associated_with	gene	0.60
RNA	contributes_to	gene	0.60
ALKBH5	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
RNA	therapeutic_target	gene	0.60
ADH1B	regulates	gene	0.60
APOE	regulates	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60