protein

FTO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

Summary

Page for FTO Protein (Fat Mass and Obesity-Associated Protein)

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🔬 Protein Info

Gene Symbol	FTO
Aliases	Fat Mass and Obesity-Associated Protein
Function	FTO (Fat Mass and Obesity-Associated Protein), also known as ALKBH9, is a 505-amino acid nuclear and cytoplasmic protein that functions as an N6-methyladenosine (m6A) demethylase.
Subcellular Localization	</strong> Nucleus, cytoplasm</div> <div class="infobox-row"><strong>Protein Fa
Molecular Weight	58.6 kDa
Amino Acids	505 aa
Pathways	autophagy, adipogenesis, IGF1 signaling, Lipid Metabolism, Oxidative Stress
GeneCards	FTO
Human Protein Atlas	FTO
Associated Diseases	Alzheimer's disease, Fat Mass And Obesity, Obesity
Known Drugs/Compounds	N6-Methyladenosine, FB23
Interactions	RNA, CERS6, UCP2, IGF1, PARP1, DNA
KG Connections	85 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FTO["<b>FTO</b>"]
    ATG5["ATG5"]
    FTO -->|"regulates"| ATG5
    ATG7["ATG7"]
    FTO -->|"regulates"| ATG7
    autophagy(["autophagy"])
    FTO -->|"activates"| autophagy
    adipogenesis(["adipogenesis"])
    FTO -->|"activates"| adipogenesis
    FTO -->|"regulates"| autophagy
    FTO -->|"regulates"| adipogenesis
    style FTO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
m6A RNA methylation	regulates	process	0.95
CDK2	targets	protein	0.95
N6-Methyladenosine	modulates	compound	0.95
Cognitive Decline	inhibits	phenotype	0.95
Metabolic Disturbances	inhibits	phenotype	0.95
ATG5	regulates	protein	0.90
ATG7	regulates	protein	0.90
autophagy	activates	pathway	0.90
adipogenesis	activates	pathway	0.90
autophagy	regulates	pathway	0.90
adipogenesis	regulates	pathway	0.90
Post-Stroke Depression	involved_in	disease	0.90
Diabetic Retinopathy	contributes_to	disease	0.90
m6A modification	inhibits	process	0.90
IGF1 signaling	modulates	pathway	0.85
STAT3	regulates	gene	0.85
ALZHEIMER'S DISEASE	modulates	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
Fat Mass And Obesity	associated_with	phenotype	0.70
Cancer	contributes_to	disease	0.65
ALS	contributes_to	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Obesity	associated_with	disease	0.65
Retinopathy	therapeutic_target	disease	0.65
Senescence	expressed_in	disease	0.65
YTHDF1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
IGF2BP1	contributes_to	gene	0.60
METTL3	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
WTAP	associated_with	gene	0.60
ALKBH5	associated_with	gene	0.60
AND	associated_with	gene	0.60
CDK2	causes	gene	0.60
DIABETIC RETINOPATHY	causes	gene	0.60
RNA	contributes_to	gene	0.60
CDK2	therapeutic_target	gene	0.60
RNA	inhibits	gene	0.60
CERS6	activates	gene	0.60
Lipid Metabolism	regulates	pathway	0.60
Macrophage	activates	cell_type	0.60
Igf	therapeutic_target	protein	0.60
Ras	associated_with	protein	0.60
Rb	associated_with	protein	0.60
EXOSOMES	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Stem Cell	expressed_in	cell_type	0.60

Incoming (22)

Source	Relation	Type	Str
FB23	inhibits	drug	0.95
Lactylation	modulates	process	0.90
GENES	contributes_to	gene	0.60
HNRNPA2B1	contributes_to	gene	0.60
WTAP	associated_with	gene	0.60
RNA	contributes_to	gene	0.60
ALKBH5	associated_with	gene	0.60
AND	associated_with	gene	0.60
CDK2	therapeutic_target	gene	0.60
IGF2BP1	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
DIABETIC RETINOPATHY	causes	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ROS	expressed_in	gene	0.60
MIRNAS	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ATP	expressed_in	gene	0.60
ADH1B	regulates	gene	0.60
APOE	regulates	gene	0.60
DNA	regulates	gene	0.60
DNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FTO

Understanding Entity Pages

Summary

Wiki Pages (20)

Epigenetic Alterations in Alzheimer's Disease

Epigenetic Mechanisms in Alzheimer's Disease

Metabolic Dysfunction in Alzheimer's Disease

Epigenetic Alterations in Alzheimer's Disease

RNA Stability and Decay

Leptin Signaling Pathway in Neurodegeneration

ATG7 Protein — Autophagy-Related Protein 7

Transcriptional Dysregulation in Neurodegeneration

mRNA Therapeutics for Neurodegenerative Diseases

RNA Metabolism Dysfunction in Corticobasal Syndrome

ATG7 Protein

VIRMA (KIAA1429) in Neurodegeneration

Section 183: Epitranscriptomics and RNA Modifications in CBS/PSP

payload-ythdf-m6a-reader-modulation-therapy

Epitranscriptomics and RNA Modifications in CBS/PSP

Prader-Willi Syndrome

VIRMA (KIAA1429)

m6A RNA Methylation Modulation Therapy for Neurodegeneration