Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YTHDF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | YTHDF1 |
| Key Genes/Proteins | PIEZO2, ATG2A, ATG14 |
| Related Diseases | Neurodegeneration, Aging, ALS, Cancer |
| Related Pathways | m6A Modification |
Knowledge base pages for this entity
graph TD
YTHDF1["YTHDF1"]
style YTHDF1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
YTHDF1 -->|"binds"| m6A_Modification["m6A Modification"]
YTHDF1 -->|"binds"| PIEZO2([PIEZO2])
YTHDF1 -->|"regulates"| Translation_Fidelity["Translation Fidelity"]
YTHDF1 -->|"involved_in"| M6a_Epitranscriptomic_Modifica["M6a Epitranscriptomic Modification"]
YTHDF1 -->|"mediates"| m6A_Epitranscriptomic_Modifica["m6A Epitranscriptomic Modification"]
YTHDF1 -->|"contributes to"| Cancer["Cancer"]
YTHDF1 -->|"interacts"| ALS["ALS"]
YTHDF1 -->|"target for"| Als["Als"]
YTHDF1 -->|"target for"| Aging["Aging"]
GENES([GENES]) -->|"contributes to"| YTHDF1
HNRNPA2B1([HNRNPA2B1]) -->|"interacts"| YTHDF1
WTAP([WTAP]) -->|"contributes to"| YTHDF1
RNA([RNA]) -->|"contributes to"| YTHDF1
ALKBH5([ALKBH5]) -->|"contributes to"| YTHDF1
AND([AND]) -->|"interacts"| YTHDF1
FTO([FTO]) -->|"contributes to"| YTHDF1
CLPP([CLPP]) -->|"target for"| YTHDF1
LONP1([LONP1]) -->|"target for"| YTHDF1
SNAP29([SNAP29]) -->|"target for"| YTHDF1| Target | Relation | Type | Str |
|---|---|---|---|
| m6A Modification | binds | process | 0.95 |
| PIEZO2 | binds | gene | 0.95 |
| PIEZO2 | regulates | gene | 0.95 |
| N6-Methyladenosine | binds | compound | 0.95 |
| m6A Modification | associated_with | mechanism | 0.89 |
| Translation Fidelity | regulates | process | 0.85 |
| ATG2A | associated_with | protein | 0.80 |
| ATG14 | associated_with | protein | 0.80 |
| M6a Epitranscriptomic Modification | involved_in | process | 0.75 |
| m6A Epitranscriptomic Modification | mediates | process | 0.75 |
| Proteostasis | modulates | process | 0.75 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Fibrosis | regulates | disease | 0.65 |
| Aging | encodes | disease | 0.65 |
| Neurodegeneration | encodes | disease | 0.65 |
| Als | encodes | disease | 0.65 |
| C1Q/C3 | associated_with | gene | 0.60 |
| RAB11 | associated_with | gene | 0.60 |
| COMPLEMENT | associated_with | gene | 0.60 |
| ELAVL2 | associated_with | gene | 0.60 |
| LONP1 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Complement | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Tdp-43 | associated_with | pathway | 0.60 |
| Mapk | associated_with | pathway | 0.60 |
| Protein Aggregation | associated_with | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| IGF2BP1 | interacts_with | gene | 0.60 |
| METTL3 | contributes_to | gene | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| ELAVL2 | therapeutic_target | gene | 0.60 |
| ALS | therapeutic_target | gene | 0.60 |
| TDP-43 | therapeutic_target | gene | 0.60 |
| STX17 | therapeutic_target | gene | 0.60 |
| BDNF | therapeutic_target | gene | 0.60 |
| FUS | therapeutic_target | gene | 0.60 |
| RAB5 | therapeutic_target | gene | 0.60 |
| MAPK | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| FUS | associated_with | gene | 0.60 |
| LYSOSOME | associated_with | gene | 0.60 |
| C1Q | associated_with | gene | 0.60 |
| MAPK | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| CLPP | associated_with | gene | 0.60 |
| IGF2BP1 | associated_with | gene | 0.60 |
| METTL3 | associated_with | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| TDP-43 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| HNRNPA2B1 | interacts_with | gene | 0.60 |
| WTAP | contributes_to | gene | 0.60 |
| RNA | contributes_to | gene | 0.60 |
| ALKBH5 | contributes_to | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| FTO | contributes_to | gene | 0.60 |
| CLPP | therapeutic_target | gene | 0.60 |
| LONP1 | therapeutic_target | gene | 0.60 |
| SNAP29 | therapeutic_target | gene | 0.60 |
| METTL3 | therapeutic_target | gene | 0.60 |
| PIEZO | regulates | gene | 0.60 |
| PIEZO1 | activates | gene | 0.60 |
| POSTN | activates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| ANG | activates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| IGF2BP1 | interacts_with | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| METTL3 | contributes_to | gene | 0.60 |
| ELAVL2 | encodes | gene | 0.60 |
| SNAP29 | encodes | gene | 0.60 |
| FUS | encodes | gene | 0.60 |
| TDP-43 | encodes | gene | 0.60 |
| STX17 | encodes | gene | 0.60 |
| RAB5 | encodes | gene | 0.60 |
| CLPP | encodes | gene | 0.60 |
| BDNF | encodes | gene | 0.60 |
| ALS | encodes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||