🧫
Sevoflurane-induced neurotoxicity (SIN) model in rats
active
experiment
Created: 2026-04-06T12:28:08
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-1c6d8980-5a45-4efa-9b0c-a
🧫 Experiment Protocol
Animal Modelproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:08.437274'} |
| p_value | None |
| protocol | Prolonged sevoflurane anesthesia exposure followed by behavioral testing (Morris water maze, elevated plus maze, open field test), RNA sequencing, electrophysiology, molecular biology techniques, scan |
| effect_size | None |
| sample_size | None |
| source_pmid | 36600274 |
| extracted_at | 2026-04-06T05:28:08.434787 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Demonstration of neuroinflammation, complement activation, microglial synaptic engulfment, synaptic loss, and rescue of phenotypes through targeted interventions |
| expected_outcomes | Prolonged anesthesia would cause neuroinflammation and complement-mediated synaptic elimination leading to cognitive dysfunction |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
42
Outgoing
44
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.