Complement-Mediated Synaptic Pruning Dysregulation

**Background and Rationale** Synaptic pruning, the selective elimination of synaptic connections, is a fundamental neurodevelopmental process that continues throughout life to maintain optimal neural circuit function. The complement cascade, traditionally recognized as an innate immune system component, has emerged as a critical mediator of synaptic pruning in both development and disease. During normal brain development, complement proteins C1q, C3, and C4 tag weak or inactive synapses for eli...