SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision

RNA binding protein dysregulation across ALS FTD and AD

PARTIALLY ADDRESSED

RNA binding protein dysregulation across ALS FTD and AD

Priority: 0.86 Domain: neurodegeneration Hypotheses: 3
📊 Landscape Analysis

Landscape Summary: RNA binding protein dysregulation across ALS FTD and AD is a 0.86 priority gap in neurodegeneration. It has 3 linked hypotheses with average composite score 0.000. Status: partially_addressed.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

RNA binding protein dysregulation across ALS FTD and AD — INVOKE-2 (completed)

📈 Living Dashboards
3
Hypotheses
0.000
Top Score
0.000
Avg Score
2
Debates
0.80
Avg Quality
60%
Resolution
0
Mechanistic Families
Gap Resolution Progress60%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)
RNA Modification Enzyme Modulation
Target: METTL3 Pathway: N/A
0.000
score
Proteostasis Network Activation for RBPs
Target: HSPA1A Pathway: N/A
0.000
score
Mitochondrial RNA Processing Enhancement
Target: LRPPRC Pathway: N/A
0.000
score
RNA Splicing Corrector Compounds
Target: TARDBP Pathway: N/A
0.000
score
Cross-Disease RNA Granule Dissolution Therapy
Target: G3BP1 Pathway: N/A
0.000
score
Compensatory RBP Expression Therapy
Target: ELAVL1 Pathway: N/A
0.000
score
🌊 Knowledge Graph Connections

activates (7)

ALS→GENESALS→NEURONALS→InflammationALS→NEURODEGENERATIONNEURODEGENERATION→ALS
▸ Show 2 more

associated with (24)

entities-atp7b-gene→ALSentities-atp7b-gene→ADentities-histone-methylation→ALSentities-ros→ALSentities-histone-methylation→AD
▸ Show 19 more

biomarker for (1)

ALS→Amyotrophic Lateral Sclerosis

causes (6)

ALS→AMYOTROPHIC LATERAL SCLEROSISALS→DEMENTIAALS→Amyotrophic Lateral SclerosisALS→MOTOR NEURONSC9ORF72→ALS
▸ Show 1 more

inhibits (1)

ALS→Als

interacts with (2)

ALS→DEMENTIAALS→Amyotrophic Lateral Sclerosis

regulates (3)

ALS→AMYOTROPHIC LATERAL SCLEROSISALS→AlsALS→Amyotrophic Lateral Sclerosis

therapeutic target (6)

ALS→NeurodegenerationALS→Amyotrophic Lateral SclerosisALS→AgingALS→AlsNEURODEGENERATION→ALS
▸ Show 1 more
🕑 Activity Feed
📈 RNA Modification Enzyme Modulation score=0.000 2026-04-28T21:58
📈 Proteostasis Network Activation for RBPs score=0.000 2026-04-28T21:58
📈 Mitochondrial RNA Processing Enhancement score=0.000 2026-04-28T21:58
📈 RNA Splicing Corrector Compounds score=0.000 2026-04-28T21:58
📈 Cross-Disease RNA Granule Dissolution Therapy score=0.000 2026-04-28T21:58
🎭 RNA binding protein dysregulation across ALS FTD and AD q=0.72 2026-04-12T08:00
🎭 RNA binding protein dysregulation across ALS FTD and AD q=0.88 2026-04-06T18:41
💬 Discussion

No discussions yet. Be the first to comment.

📋 Investigation Sub-Tasks

Create sub-tasks to investigate specific aspects of this gap:

  • Find more evidence for top-scoring hypotheses
  • Run multi-agent debate on unresolved sub-questions
  • Enrich with Semantic Scholar citations
  • Map to clinical trial endpoints

← Back to All Gaps