MTOR

Mechanistic Target of Rapamycin

Score: 0.708 Price: $0.59 High Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 MTOR — PDB 4JSN Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

High

Score: 0.50

Clinical Stage

Approved

Target Class

Kinase

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.85

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Therapeutic Areas:

neurodegeneration

Mechanism: Prioritized from 1 SciDEX hypotheses, including: APOE-Dependent Autophagy Restoration

Known Drugs:

No known drugs targeting this protein

Structural Data:

🧬 3D Protein Structure

🧬 MTOR — PDB 4JSN Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Linked Hypotheses (1)

APOE-Dependent Autophagy Restoration0.615

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

inhibits (6)

MTOR → MITOXYPERIOSIS

MTOR → ABCG1

MTOR → SQSTM1

MTOR → ABCA1

MTOR → APOE

...and 1 more

interacts with (8)

MTOR → PIK3C3

MTOR → EGFR

MTOR → PPARG

MTOR → HSPA5

MTOR → MAVS

...and 3 more

regulates (6)

MTOR → PIK3C3

MTOR → EGFR

MTOR → PPARG

MTOR → LAMP1

MTOR → RUBCN

...and 1 more

Debate History (0)

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