MTOR

Mechanistic Target of Rapamycin

Score: 0.419 Price: $0.42 Low Druggability Status: active Wiki: MTOR Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 MTOR — PDB 4JSN Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Low

Score: 0.32

Clinical Stage

Phase I

Target Class

Kinase

Safety

0.50

Druggability Analysis

Drug Development0.15

Structural Tractability0.30

Target Class0.85

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (10 compounds)

10 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: APOE-Dependent Autophagy Restoration

Drug Pipeline (10 compounds)

10 Preclinical

Known Drugs:

CHEMBL435507 (preclinical)

CHEMBL104468 (preclinical)

CHEMBL179242 (preclinical)

CHEMBL188678 (preclinical)

CHEMBL411735 (preclinical)

CHEMBL265123 (preclinical)

WORTMANNIN (preclinical)

CHEMBL371029 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: P42345

🧬 3D Protein Structure

🧬 MTOR — PDB 4JSN Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for P42345

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Clinical Trials (2)

Relevant trials from ClinicalTrials.gov

Active

Completed

Total Enrollment

By Phase

EARLY_PHASE1: 1 · PHASE1: 1

Tamoxifen Treatment in Patients With Motor Neuron Disease Completed

PHASE1 NCT02166944 n=20

Amyotrophic Lateral Sclerosis, ALS Functional Ration Scale, TAR-DNA-binding Protein-43

Interventions: tamoxifen 40 mg daily for one year

Sponsor: Taipei Medical University Shuang Ho Hospital | Started: 2014-04

Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway Completed

EARLY_PHASE1 NCT04200911 n=10

Cognitive Impairment, Mild, Alzheimer Disease

Interventions: Rapamune

Sponsor: The University of Texas Health Science Center at San Antonio | Started: 2020-06-01

Linked Hypotheses (6)

APOE-Dependent Autophagy Restoration0.895

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericytes0.578

Metabolic Checkpoint Reprogramming via TREM2-mTOR Axis0.455

Microglial Autophagy Priming Therapy0.000

Temporal mTOR Modulation for Sequential A1/A2 Switching0.000

mTOR Inhibition Promotes Astrocytic Clearance of Inflammatory Proteins0.000

Linked Experiments (8)

Proximity labeling approach combined with proteomics identified subcellular molecular architecture o0.500

Proximity labeling proteomics in mouse brains revealed similar spheroid abnormalities in protein tur0.500

iPSC-derived AD model with optical electrophysiology enabled mechanistic investigation of spheroid f0.500

mTOR inhibition in mice ameliorated spheroid pathology, demonstrating therapeutic potential of targe0.500

Phosphorylated mTOR levels in spheroids correlated with AD severity in human postmortem brains, link0.500

Human iPSC-derived AD model with optical electrophysiology demonstrated that mTOR inhibition amelior0.500

mTOR inhibition in mouse AD model ameliorated spheroid pathology.0.500

Phosphorylated mTOR levels in axonal spheroids correlated with AD severity in human postmortem brain0.500

Scoring Dimensions

Knowledge Graph (20)

▸ Show 6 more

PPARA→MTORCAT→MTORSQSTM1→MTORRPS6KB1→MTORRAB7A→MTORSREBF1→MTOR

Debate History (1)

Should MTOR (Mechanistic Target of Rapamycin) be prioritized as a therapeutic ta2026-04-22

MTOR

3D Protein Structure

Druggability & Clinical Context

🧬 3D Protein Structure

3D Protein Structure (AlphaFold)

Clinical Trials (2)

Linked Hypotheses (6)

Linked Experiments (8)

Scoring Dimensions

Knowledge Graph (20)

activates (4)

associated with (1)

inhibits (2)

participates in (2)

regulates (11)

Debate History (1)