gene 603 words KG: TRAF6 2026-03-24
kind:genesection:genesstate:published
Contents

TRAF6 Gene

🧬 Gene Info
Gene SymbolTRAF6
Full NameTRAF6
Chromosome11p12
Protein TypeGene
FunctionTRAF6 is a central signaling molecule in multiple pathways
Molecular Weight60 kDa
Amino Acids524 aa
PathwaysNF-κB signaling, NF-κB, MAPK
NCBI Gene IDSearch NCBI
GeneCardsTRAF6
Human Protein AtlasTRAF6
Associated DiseasesAls, Atherosclerosis, Autoimmune, Cancer, Encephalitis, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsCHUK, PRDX6, MAPK14, BECN1, TNF, ECSIT
KG Connections591 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (14)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: inhibits
ATG9A Gene
gene · KG edge: activates
ATG7 Gene
gene · KG edge: inhibits
ATG5 — Autophagy Related 5
gene · KG edge: regulates

Knowledge Graph (12 edges)

TRAF6 associated_with CHOP
TRAF6 associated_with NRF2
TRAF6 associated_with MTOR
TRAF6 associated_with BECLIN1
TRAF6 associated_with BCL2
TRAF6 associated_with TAAR1
TRAF6 associated_with SIGMAR1
TRAF6 associated_with MYD88
TRAF6 associated_with PUMA
TRAF6 activates NFKB1