gene 711 words KG: CYP3A4
kind:genesection:genesstate:published
Contents

CYP3A4 — Cytochrome P450 3A4

🧬 Gene Info
Gene SymbolCYP3A4
Full NameCytochrome P450 3A4
Chromosome7q21.1
FunctionCYP3A4 encodes cytochrome P450 3A4, which plays a critical role in
Primary Expressionthe liver and intestinal mucosa
PathwaysOxidative Stress
UniProt ID[P08684](https://www.uniprot.org/uniprot/P08684)
Ensembl IDENSG00000123338
OMIM171696
GeneCardsCYP3A4
Human Protein AtlasCYP3A4
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Anxiety
Known Drugs/Compoundsanxiolytic drugs
InteractionsJUN, PDK1, EGFR, ERCC3, CEBPB, AKT
KG Connections311 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (27)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Noradrenergic-Tau Propagation Blockade
Score: 0.51
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (6)

Alzheimer Indonesia
institution · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with
ADRA2A Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: therapeutic_target
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CYP3A4 regulates MTOR
CYP3A4 associated_with ABCG2
CYP3A4 associated_with ADRB2
CYP3A4 associated_with SNCA
CYP3A4 associated_with SLC6A2
CYP3A4 activates JUN
CYP3A4 associated_with SLC6A3
CYP3A4 associated_with ABCB1
CYP3A4 associated_with CYP2D6
CYP3A4 associated_with SLC6A4