Metabolic Checkpoint Reprogramming via TREM2-mTOR Axis

flowchart TD
    A["APOE4 Microglial Dysfunction<br/>TREM2 mTORC1 Axis Dysregulated"]
    B["mTORC1 Hyperactivation<br/>TREM2-Akt-mTOR Pathway"]
    C["Oxidative Phosphorylation Suppressed<br/>Glycolytic Shift in Microglia"]
    D["Inflammatory Priming<br/>Pro-Inflammatory Gene Program"]
    E["CNS-Penetrant mTOR Modulator<br/>Rapamycin Analog Torin-2"]
    F["mTORC1 Partial Inhibition<br/>Metabolic Flexibility Restored"]
    G["OXPHOS Re-Engaged<br/>Anti-Inflammatory Phenotype"]
    H["Inflammatory Responsiveness Preserved<br/>Not Full Immunosuppression"]
    I["APOE4 Microglial Rescue<br/>AD Neuroinflammation Reduced"]
    A --> B
    B --> C
    C --> D
    E --> F
    F --> G
    F --> H
    G --> I
    H --> I
    style B fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style I fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7