Contents

NAMPT Gene

🧬 Gene Info

Gene Symbol	NAMPT
Full Name	Nicotinamide Phosphoribosyltransferase
Aliases	Visfatin, PBEF, PBEF1
Chromosome	7q22.3
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule competitive inhibitors of NAD+ biosynthesis enzyme
Mechanism of Action	Small molecule competitive inhibitors of NAD+ biosynthesis enzyme
Druggability	Low (0.45)
Clinical Stage	Phase II
Molecular Weight	52 kDa
Gene Type	Protein Coding
Pathways	Akt, Angiogenesis, Autophagy, Cerebrovascular, Cholesterol Metabolism
UniProt ID	Q99714
NCBI Gene ID	10135
Ensembl ID	ENSG00000105835
OMIM	608064
GeneCards	NAMPT
Human Protein Atlas	NAMPT
Associated Diseases	ALS, ALZHEIMER, Aging, Atherosclerosis
Known Drugs/Compounds	nicotinamide, NAMPT positive allosteric modulators
Interactions	CD38, SIRT6, EGR2, PARP1, SIRT1, Rb
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Metabolic NAD+ Salvage Pathway Enhancement Through TREM2 R47H Variant-Driven Metabolic Dysfunction as
KG Connections	611 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph