gene 2,543 words KG: P2RY1
Contents

P2RY1 Gene

🧬 Gene Info
Gene SymbolP2RY1
Full NamePurinergic Receptor P2Y1
Chromosome19p13.2
Protein FamilyP2Y receptor family (GPCR)
Protein TypeGpcr
Target ClassGpcr
FunctionGPCR antagonists or agonists modulating purinergic signaling
Mechanism of ActionGPCR antagonists or agonists modulating purinergic signaling
DruggabilityLow (0.41)
Clinical StagePhase I
Molecular Weight41 kDa
Exons2
PathwaysSpontaneous Bursting Activity
UniProt IDP47900
NCBI Gene ID5028
Ensembl IDENSG00000142203
OMIM181010
GeneCardsP2RY1
Human Protein AtlasP2RY1
Associated DiseasesAls, ALZHEIMER, DIABETES, epilepsy
Known Drugs/CompoundsMRS2500
Interactionsadora2b, ADORA2B, ATP, F3, GENES, P2RX1
SciDEX TargetView Target Profile (2 clinical trials)
KG Connections222 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (26)

Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Gamma entrainment restores astrocyte-neuron metabolic coupli
Score: 0.70
Microglial P2Y12-Dependent Territorial Segregation of Synapt
Score: 0.70
Loss of Homeostatic Epigenetic Identity Reprograms Microglia
Score: 0.65
TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs
Score: 0.65
P2RY12-mediated autophagy inhibition in cerebral VSMCs impai
Score: 0.60
P2RY12-driven autophagy impairment in cerebral VSMCs mediate
Score: 0.58
Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) a
Score: 0.58
Female Microglia Exhibit Reduced P2Y12 Expression Conferring
Score: 0.58
TREM2-P2RY12 Balance Restoration Therapy
Score: 0.57
oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation
Score: 0.55
miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcr
Score: 0.52
LRP1 Loss-of-Function Derepresses P2RY12 Expression
Score: 0.50
P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring
Score: 0.49
Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulatio
Score: 0.48
Cerebral VSMC foam cells induce pericyte detachment via PDGF
Score: 0.47
Purinergic-Metabolic Coupling Restoration
Score: 0.46
DNA Hypomethylation at P2RY12 Promoter Correlates with Disea
Score: 0.44
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Knowledge Graph (12 edges)

P2RY1 interacts_with P2RX7
P2RY1 associated_with neurodegeneration
P2RX7 interacts_with P2RY1
BMAL1 co_discussed P2RY1
HK2 co_discussed P2RY1
MIRO1 co_discussed P2RY1
P2RY1 co_discussed SOAT1
P2RY1 co_discussed KCNK2
P2RY1 co_discussed TET2
P2RY1 co_discussed PIEZO1

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