gene

P2RX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

Summary

P2RX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with ALS, Als, Covid. Connected to 39 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RX1
Chromosome	17p13.2
Protein Type	Channel
Function	encodes a member of the P2X family of ATP-gated ion channels.
Primary Expression	various tissues including smooth muscle, platelets, immune cells, and sensory neurons, where they play critical roles in physiological and pathologica
Amino Acids	395 aa
UniProt ID	P47856
NCBI Gene ID	5022
Ensembl ID	ENSG00000130223
OMIM	167360
GeneCards	P2RX1
Human Protein Atlas	P2RX1
Official Symbol	P2RX1
Official Full Name	Purinergic Receptor P2X Ligand-Gated Ion Channel 1
Protein Length	395 amino acids
Associated Diseases	ALS, Inflammation
Interactions	P2RX4, P2RX7, P2RY1, P2RX5, PANX1, P2RY12
KG Connections	83 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: P2RX1 — AlphaFold P47856 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    P2RX1["<b>P2RX1</b>"]
    Als{"Als"}
    P2RX1 -->|"associated with"| Als
    Inflammation{"Inflammation"}
    P2RX1 -->|"associated with"| Inflammation
    Covid{"Covid"}
    P2RX1 -->|"activates"| Covid
    ALS{"ALS"}
    P2RX1 -->|"associated with"| ALS
    P2RX4["P2RX4"]
    P2RX1 -->|"therapeutic target"| P2RX4
    P2RX7["P2RX7"]
    P2RX1 -->|"therapeutic target"| P2RX7
    P2RY14["P2RY14"]
    P2RX1 -->|"therapeutic target"| P2RY14
    P2RY1["P2RY1"]
    P2RX1 -->|"therapeutic target"| P2RY1
    P2RX1 -->|"activates"| P2RX4
    P2RX1 -->|"activates"| P2RX7
    CD38["CD38"]
    P2RX1 -->|"associated with"| CD38
    P2RX1 -->|"activates"| P2RY1
    ADORA2B["ADORA2B"]
    ADORA2B -->|"activates"| P2RX1
    P2RY12["P2RY12"]
    P2RY12 -->|"activates"| P2RX1
    P2RY1 -->|"therapeutic target"| P2RX1
    P2RX4 -->|"therapeutic target"| P2RX1
    P2RY1 -->|"activates"| P2RX1
    P2RX7 -->|"activates"| P2RX1
    P2RX4 -->|"activates"| P2RX1
    PANX1["PANX1"]
    PANX1 -->|"activates"| P2RX1
    GENES["GENES"]
    GENES -->|"activates"| P2RX1
    CD38 -->|"associated with"| P2RX1
    ATP["ATP"]
    ATP -->|"expressed in"| P2RX1
    P2RY14 -->|"expressed in"| P2RX1
    style P2RX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

Target	Relation	Type	Str
LUNG TISSUE	expressed_in	entity	0.95
UPREGULATES	upregulates	entity	0.95
IMMUNE CELLS	expressed_in	entity	0.90
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
COVID-19	upregulates	disease	0.85
Immune Cells	expressed_in	cell_type	0.80
COVID-19	upregulated_in	disease	0.80
coagulation	associated_with	pathway	0.75
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Covid	activates	disease	0.65
ALS	associated_with	disease	0.65
P2RX4	therapeutic_target	gene	0.60
P2RX7	therapeutic_target	gene	0.60
P2RY14	therapeutic_target	gene	0.60
P2RY1	therapeutic_target	gene	0.60
P2RX4	activates	gene	0.60
P2RX7	activates	gene	0.60
CD38	associated_with	gene	0.60
P2RY1	activates	gene	0.60
P2RX5	activates	gene	0.60
PANX1	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX7	expressed_in	gene	0.60
P2RX4	expressed_in	gene	0.60
P2RY1	expressed_in	entity	0.60
P2RY14	expressed_in	entity	0.60
P2RX4	regulates	entity	0.60
P2RX5	regulates	entity	0.60
P2RX7	regulates	entity	0.60
P2RY1	regulates	entity	0.60
P2RY12	regulates	entity	0.60
PANX1	regulates	entity	0.60
ADORA2B	activates	gene	0.60
SPTLC2	activates	gene	0.60
SYNE2	activates	gene	0.60
NAD	associated_with	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	expressed_in	gene	0.60
AND	activates	gene	0.60
ATP	therapeutic_target	gene	0.60
App	therapeutic_target	protein	0.60
ATP	associated_with	gene	0.60
App	associated_with	protein	0.60
P2RX4	co_expressed_with	gene	0.50
P2RX5	co_expressed_with	gene	0.50
disease	expressed_in	disease	0.50
Asthma	expressed_in	disease	0.50
GENE EXPRESSION	activates	concept	0.50

Incoming (33)

Source	Relation	Type	Str
ADORA2B	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RY1	therapeutic_target	gene	0.60
P2RX4	therapeutic_target	gene	0.60
P2RY1	activates	gene	0.60
P2RX7	activates	gene	0.60
P2RX4	activates	gene	0.60
PANX1	activates	gene	0.60
CD38	associated_with	gene	0.60
P2RY14	expressed_in	gene	0.60
P2RY1	expressed_in	gene	0.60
P2RX4	expressed_in	gene	0.60
P2RX7	expressed_in	gene	0.60
P2RX5	activates	gene	0.60
ADORA2B	regulates	entity	0.60
P2RX7	therapeutic_target	gene	0.60
P2RY14	therapeutic_target	gene	0.60
F3	activates	gene	0.60
ADRA2A	activates	gene	0.60
ALDH1A2	activates	gene	0.60
IDH1	activates	gene	0.60
ITPKA	activates	gene	0.60
LPL	activates	gene	0.60
GENES	activates	gene	0.60
ATP	expressed_in	gene	0.60
ATP	associated_with	gene	0.60
NAD	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ATP	therapeutic_target	gene	0.60
IRS1	activates	gene	0.60
CD38	co_expressed_with	gene	0.50
adora2b	activates	gene	0.50
ATP	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

P2RX1

Understanding Entity Pages

Summary

Wiki Pages (7)

P2RX1 Gene

P2RX5 Gene

P2X1 Receptor Protein

PANX1 Protein

PANX1 Gene