biomarker 1,103 words KG: NFH 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Neurofilament Heavy Chain (NfH)

🔬 Protein Info
Gene SymbolNFH
Chromosome22q12.2
Functionis a neuronal intermediate filament protein encoded by the NEFH gene on chromosome 22q12.
Molecular Weight200 kDa
Amino Acids816 aa
Exons4
GeneCardsNFH
Human Protein AtlasNFH
CategoryAxonal Injury Biomarker
TargetNfH protein in CSF/blood
Sample TypeCSF, Plasma, Serum
Clinical UtilityDisease progression, treatment response
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming
Score: 0.61
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.60
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S
Score: 0.60
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (2)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (6)

Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

XIAP
gene · KG edge: biomarker_for
TNFRSF1A Gene
gene · KG edge: biomarker_for
RIPK1 Gene
gene · KG edge: associated_with
NFKBIA Gene (NFKB Inhibitor Alpha)
gene · KG edge: associated_with
IL1B Gene - Interleukin 1 Beta
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NFH biomarker_for TNFRSF1A
NFH associated_with IKBKB
NFH therapeutic_target Ms
NFH biomarker_for Akt
BCL2L1 biomarker_for NFH
CASP1 associated_with NFH
NFKBIA associated_with NFH
CASP8 biomarker_for NFH
IL1B associated_with NFH
XIAP biomarker_for NFH