gene 1,909 words KG: RIPK1 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:alstopic:neuroinflammation
Contents

RIPK1 Gene

🧬 Gene Info
Gene SymbolRIPK1
AliasesRIP1, RIPK1, Receptor-Interacting Protein Kinase 1
Chromosome6p25.2
Protein TypeKinase
FunctionComplex I formation: TNFR1 recruits TRADD, RIPK1, TRAF2/5, and cIAP1/2 into a membrane-associated complex
Molecular Weight75 kDa
Amino Acids671 aa
Exons9
PathwaysNF-κB signaling, NF-κB
UniProt IDQ13546
NCBI Gene ID8767
GeneCardsRIPK1
Human Protein AtlasRIPK1
Gene NameReceptor-Interacting Serine/Threonine Kinase 1
Protein Length671 amino acids
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/CompoundsRAPAMYCIN, Cadmium, Metformin, rapamycin, metformin, Necrostatin
InteractionsMAPK14, BECN1, ATF6, DDIT3, NBR1, HSP70
KG Connections1508 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Blood-Brain Barrier SPM Shuttle System
Score: 0.55
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates
AKT1 Gene
gene · KG edge: interacts_with
AIF Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

RIPK1 co_discussed SQSTM1
RIPK1 co_discussed STAT3
RIPK1 co_discussed STING
RIPK1 co_discussed RIPK3
RIPK1 co_discussed SOD1
RIPK1 mediates TNF
RIPK1 regulates BAX
RIPK1 phosphorylates RPS6KB1
RIPK1 phosphorylates RPTOR
RIPK1 phosphorylates SQSTM1