gene 611 words KG: TNFRSF1A 2026-03-23
kind:genesection:genesstate:published
Contents

TNFRSF1A Gene

🧬 Gene Info
Gene SymbolTNFRSF1A
Full NameTumor necrosis factor receptor superfamily member 1A
AliasesTNFR1
Chromosome12p13.31
FunctionTNFRSF1A encodes TNFR1, a receptor that plays central roles in inflammation and cell survival:
Molecular Weight55 kDa
Amino Acids455 aa
Exons10
PathwaysNF-κB Signaling, NF-κB, MAPK Pathway, MAPK
UniProt IDP19438
NCBI Gene ID7132
Ensembl IDENSG00000082258
OMIM191190
GeneCardsTNFRSF1A
Human Protein AtlasTNFRSF1A
Associated DiseasesAtherosclerosis, Diabetes, Ms
InteractionsOCLN, ICAM1, BMAL1, ARNT, TNF, CRY1
KG Connections154 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
CRY1 Gene
gene · KG edge: activates
CFLAR
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TNFRSF1A activates OCLN
TNFRSF1A activates ICAM1
TNFRSF1A activates BMAL1
TNFRSF1A activates ARNT
TNFRSF1A regulates CX3CR1
TNFRSF1A expressed_in CXCR4
TNFRSF1A associated_with IKBKB
TNFRSF1A activates TNF
TNFRSF1A activates CRY1
TNFRSF1A activates IBA1