gene 2,533 words KG: CASP8
Contents

CASP8 Gene

🧬 Gene Info
Gene SymbolCASP8
Full NameCaspase 8
Chromosome2q33
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight20 kDa
Amino Acids80 aa
PathwaysAkt, Nf-Κb, Pi3K, Toll-Like Receptor
UniProt ID[Q14790](https://www.uniprot.org/uniprot/Q14790)
Ensembl IDENSG00000164040
GeneCardsCASP8
Human Protein AtlasCASP8
Associated DiseasesAls, Autoimmune, Ms, Rheumatoid Arthritis
Known Drugs/Compoundsnatural products
InteractionsSQSTM1, MMP2, CASP3, GBM, CDK4, MCL1
KG Connections177 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: therapeutic_target
CASP6 — Caspase-6
gene · KG edge: cleaves

Knowledge Graph (12 edges)

CASP8 activates SQSTM1
CASP8 therapeutic_target P62
CASP8 interacts_with MMP2
CASP8 interacts_with CASP3
CASP8 interacts_with GBM
CASP8 interacts_with CDK4
CASP8 interacts_with MCL1
CASP8 associated_with CASP3
CASP8 associated_with PPARG
CASP8 associated_with ATM