| Gene Symbol | AKT1 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons. |
| Amino Acids | 480 aa |
| Pathways | Akt, Apoptosis, Autophagy, Immune Response, Mapk |
| Ensembl ID | ENSG00000142208 |
| GeneCards | AKT1 |
| Human Protein Atlas | AKT1 |
| Agent | Mechanism |
| IGF-1 | Receptor-mediated PI3K activation |
| Insulin (intranasal) | InsR-mediated AKT1 activation |
| GLP-1 agonists | Indirect PI3K/AKT activation |
| TrkB agonists | BDNF receptor-mediated activation |
| PIP3 | Activator |
| PDK1 | Kinase |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's Disease, Ataxia |
| Known Drugs/Compounds | Atbc, Andrographis paniculata, quercetin, Ipatasertib, Transcranial near-infrared light, berberine |
| Interactions | SQSTM1, RPS6KB1, GRB2, RHEB, STING1, EIF2A |
| KG Connections | 1615 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |