biomarker 1,446 words KG: SYNAPTOPHYSIN
Contents

Synaptophysin - Synaptic Biomarker

🔬 Protein Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesALS, Epilepsy, Ms
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ANXIETY, APP
KG Connections309 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (55)

Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
← Prevpg 3/3

Related Analyses (26)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40

See Also (7)

blarcamesine-axon
clinical_trial · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
ATG9A Gene
gene · KG edge: co-localizes
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

SYNAPTOPHYSIN biomarker_for BACE1
SYNAPTOPHYSIN biomarker_for NFL
BACE1 biomarker_for SYNAPTOPHYSIN
TNF activates SYNAPTOPHYSIN
APP activates SYNAPTOPHYSIN
SYNAPTOPHYSIN activates IL6
SYNAPTOPHYSIN activates BDNF
SYNAPTOPHYSIN activates GFAP
NFL biomarker_for SYNAPTOPHYSIN
ATG9A co-localizes SYNAPTOPHYSIN

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