biomarker 1,446 words KG: SYNAPTOPHYSIN 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Synaptophysin - Synaptic Biomarker

🔬 Protein Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesALS, Epilepsy, Ms
InteractionsIL6, BDNF, GFAP, RAB5, GDI1, RAB3A
KG Connections315 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.69
Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Heterogeneous astrocyte activation states differentially imp
Score: 0.52
Layer V excitatory neurons show selectively enhanced vulnera
Score: 0.51
Astrocyte-Mediated Microglial Memory Erasure
Score: 0.46

Related Analyses (26)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
ATG9A Gene
gene · KG edge: co-localizes
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for

Knowledge Graph (12 edges)

SYNAPTOPHYSIN biomarker_for BACE1
SYNAPTOPHYSIN biomarker_for NFL
SYNAPTOPHYSIN activates IL6
SYNAPTOPHYSIN activates BDNF
SYNAPTOPHYSIN activates GFAP
SYNAPTOPHYSIN activates RAB5
SYNAPTOPHYSIN expressed_in ATG9A
SYNAPTOPHYSIN protects_against CASP1
SYNAPTOPHYSIN protects_against VEGF
SYNAPTOPHYSIN associated_with GFAP