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gene 1,670 words KG: C2
Contents

C2 (Complement Component 2)

🧬 Gene Info
Gene SymbolC2
Full NameComplement Component 2
Chromosome6p21.3
Functionencodes a 732-amino acid zymogen that, upon activation, generates the C3 convertase complex essential for complement cascade amplification.
Molecular Weight83 kDa
Amino Acids732 aa
Exons18
UniProt IDP06610
NCBI Gene ID717
Ensembl IDENSG00000166278
OMIM120490
GeneCardsC2
Human Protein AtlasC2
Associated Diseasesautism spectrum disorder
InteractionsMAVS, PI3KC3, SIRT2
KG Connections17 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.89EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia
Score: 0.71GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection I
Score: 0.68mTORC1 Reactivation as Autophagy-Senescence Divergence Point
Score: 0.68Metabolic Checkpoint Failure in NG2+ Oligodendrocyte Progeni
Score: 0.68Epigenetic Priming Ketone Protocol
Score: 0.66HDAC2 Phospho-Lock Window for Synaptic Gene Silencing
Score: 0.64Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recov
Score: 0.64Nuclear Export Deficits Increase Cytosolic TDP-43 Burden
Score: 0.58Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabiliz
Score: 0.58Direct neuronal HDAC inhibition is unlikely to mediate thera
Score: 0.56Gut-derived butyrate reprograms microglia for amyloid cleara
Score: 0.53HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp
Score: 0.52VDAC1 Hyper-Oligomerization via Direct TDP-43 Binding
Score: 0.50Structured Intronic Scaffold Regions in Enhancer-dilncRNAs E
Score: 0.49cAMP/PKA-Dependent Transcription Factor Activation via Nutri
Score: 0.42HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site
Score: 0.41Dicer-Processed siRNA-Mediated Transcript Silencing
Score: 0.41Gut butyrate deficiency impairs microglial amyloid clearance
Score: 0.38Mitochondrial Pyruvate Carrier Inhibition to Force Metabolic
Score: 0.35
pg 1/2Next →

Knowledge Graph (12 edges)

C2 inhibits SIRT2
C2 associated_with TGFB1
C2 associated_with C3
C2 associated_with C5
C2 activates MAVS
C2 expressed_in C6
C2 inhibits Huntington's disease
C2 associated_with autism spectrum disorder
C2 interacts_with PI3KC3
C2 participates_in PI3K-AKT-mTOR signaling

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