SIRT2

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Sirtuin 2 - NAD+-dependent deacetylase regulating microtubule acetylation, oxidative stress, and neurodegeneration in Parkinson's and Alzheimer's disease.

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flowchart TD
    SIRT2["SIRT2"] -->|"regulates"| Inflammation["Inflammation"]
    SIRT2["SIRT2"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    SIRT2["SIRT2"] -->|"associated with"| Parkinson["Parkinson"]
    SIRT2["SIRT2"] -->|"associated with"| Alzheimer["Alzheimer"]
    SIRT2["SIRT2"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    SIRT2["SIRT2"] -->|"associated with"| Huntington["Huntington"]
    SIRT2["SIRT2"] -->|"regulates"| Ms["Ms"]
    SIRT2["SIRT2"] -->|"regulates"| Als["Als"]
    SIRT2["SIRT2"] -->|"associated with"| Inflammation["Inflammation"]
    SIRT2["SIRT2"] -.->|"inhibits"| Alzheimer["Alzheimer"]
    SIRT2["SIRT2"] -.->|"inhibits"| Als["Als"]
    SIRT2["SIRT2"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    style SIRT2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0