gene

PI3KC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3KC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	PIK3C3
Full Name	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3
Aliases	VPS34, hVps34
Chromosome	18q12.3
Function	Class III PI3K (VPS34). Generates PI3P for autophagosome formation and endosomal sorting. Critical for neuronal autophagy.
Primary Expression	Ubiquitous; enriched in neurons
Molecular Weight	101.5 kDa
Gene Type	Protein-coding
Pathways	Autophagy, Endosomal sorting, mTOR signaling
GeneCards	PIK3C3
Human Protein Atlas	PIK3C3
Associated Diseases	Alzheimer disease, Parkinson disease, Huntington disease
Interactions	AUTOPHAGY, FIP200, ATG14, ULK1, AND, CYTOKINES
KG Connections	109 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: PI3KC3 — AlphaFold Q8NEB9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3KC3["PI3KC3"] -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    PI3KC3["PI3KC3"] -->|"regulates"| Autophagy["Autophagy"]
    PI3KC3["PI3KC3"] -->|"interacts"| Als["Als"]
    PI3KC3["PI3KC3"] -->|"interacts"| Autophagy_1["Autophagy"]
    PI3KC3["PI3KC3"] -->|"regulates"| ATG14["ATG14"]
    PI3KC3["PI3KC3"] -->|"activates"| Autophagy_2["Autophagy"]
    NRBF2["NRBF2"] -->|"regulates"| PI3KC3["PI3KC3"]
    BECN1["BECN1"] -->|"interacts"| PI3KC3["PI3KC3"]
    ATG13["ATG13"] -->|"associated"| PI3KC3["PI3KC3"]
    APP["APP"] -->|"regulates"| PI3KC3["PI3KC3"]
    style PI3KC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (66)

Target	Relation	Type	Str
autophagy activation	regulates	process	0.85
AUTOPHAGY	regulates	gene	0.80
Autophagy	regulates	pathway	0.80
Als	interacts_with	disease	0.75
Autophagy	interacts_with	pathway	0.70
ATG14	regulates	gene	0.70
Autophagy	activates	pathway	0.70
Ms	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ulcerative Colitis	regulates	disease	0.65
Inflammation	interacts_with	disease	0.65
Infection	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Viral Infection	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Infection	regulates	disease	0.65
Als	activates	disease	0.65
AUTOPHAGY	interacts_with	gene	0.60
Pi3K	interacts_with	pathway	0.60
FIP200	interacts_with	gene	0.60
ATG14	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
Pi3K	regulates	pathway	0.60
UBIQUITIN	regulates	gene	0.60
ULK1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Tumor Microenvironment	activates	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
MTOR	therapeutic_target	gene	0.60
Immunotherapy	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
AND	activates	gene	0.60
CYTOKINES	activates	gene	0.60
JAK2	activates	gene	0.60
BECN1	activates	gene	0.60
CANCER	activates	gene	0.60
IL-6	activates	gene	0.60

Incoming (43)

Source	Relation	Type	Str
NRBF2	regulates	protein	0.70
BECN1	interacts_with	gene	0.60
ATG13	associated_with	gene	0.60
APP	regulates	gene	0.60
RAB7	regulates	gene	0.60
ALZHEIMER DISEASE	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
SQSTM1	regulates	gene	0.60
P62	regulates	gene	0.60
ATG8	regulates	gene	0.60
LC3	regulates	gene	0.60
BECN1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-6	activates	gene	0.60
JAK2	activates	gene	0.60
CANCER	activates	gene	0.60
PIK3C3	regulates	gene	0.60
BECN1	regulates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
BCL-2	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
VIRAL INFECTIONS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ATG5	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ATG14	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
AMPK	regulates	gene	0.60
C2	interacts_with	gene	0.60
ATG14	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
FIP200	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3KC3

Understanding Entity Pages

Wiki Pages (11)

autophagy-lysosome-dysfunction

BECN1 Protein (Beclin-1)

AMBRA1 Gene

C2 (Complement Component 2)

becn1-autophagy-initiation-neurodegeneration-causal-chain

ATG14 Protein

Beclin-1

BPAN — Beta-Propeller Protein-Associated Neurodegeneration

Beclin 1 (BECN1)