cell 604 words KG: ent-gene-16cf4081 2026-03-24
kind:cell-typesection:cell-typesstate:published
Contents

CSF1R-Inhibited Microglia

🔬 Protein Info
Gene SymbolCSF1R
Full NameInhibited Microglia
AliasesColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionUpon ligand binding, CSF1R undergoes
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesALS, Alzheimer, Anxiety, Atherosclerosis, CSF1R-related Leukoencephalopathy
Known Drugs/CompoundsKETAMINE, NICOTINAMIDE, PLX3397, PLX5622, nicotinamide, dasatinib
InteractionsSTAT5, MECP2, JAK2, PDGFRB, BDNF, CX3CR1
KG Connections586 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Orexin-Microglia Modulation Therapy
Score: 0.49

Related Analyses (19)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (3)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40