| Gene Symbol | PINK1 |
| Full Name | Deficient Dopaminergic Neurons in Parkinson's Disease |
| Chromosome | 1p36.12 |
| Protein Family | Serine/threonine kinase family |
| Protein Type | Kinase |
| Function | is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021]. |
| Primary Expression | Mitochondrial outer membrane |
| Subcellular Localization | mitochondria in neurons. [@valente2004] |
| Molecular Weight | 63 kDa |
| Pathways | Amyloid, Apoptosis, Autophagy, Chaperone, Cholesterol |
| UniProt ID | Q9BXM7 |
| NCBI Gene ID | 65018 |
| Ensembl ID | ENSG00000158828 |
| OMIM | 608309 |
| GeneCards | PINK1 |
| Human Protein Atlas | PINK1 |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | BGP-15, Canagliflozin, CANAGLIFLOZIN, DEFERIPRONE, dimethyl fumarate, Gastrodin |
| Interactions | ABCD3, ABP, ACHE, Actin, AD, AGING |
| SciDEX Hypotheses | Dose-Response Framework: PINK1/Parkin Mitophagy as Mitophagy collapse via PINK1-PRKN is the primary a PINK1/PARK2-Mediated Mitophagy Enhancement for Neu (+5 more) |
| KG Connections | 3557 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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