| Gene Symbol | CHCHD2 |
| Chromosome | 7p13 |
| Protein Family | Coiled-Coil-Helix-Coiled-Coil-Helix (CHCHD) domain proteins |
| Protein Type | Protein |
| Function | is a small mitochondrial protein that plays critical roles in mitochondrial function, cellular metabolism, and Parkinson's disease (PD) pathogenesis. |
| Primary Expression | dopaminergic neurons of the substantia nigra pars compacta, explaining the selective vulnerability of these neurons in PD |
| Subcellular Localization | the intermembrane space, where it plays important roles in mitochondrial function, particularly in response to oxidative |
| Molecular Weight | 26 kDa |
| Amino Acids | 182 aa |
| Pathways | Mitophagy |
| UniProt ID | Search UniProt |
| GeneCards | CHCHD2 |
| Human Protein Atlas | CHCHD2 |
| Coiled-coil helix domain | Mediates protein-protein interactions |
| C-terminal region | Contains conserved cysteine residues for metal binding |
| Associated Diseases | Aging, ALS, Amyotrophic Lateral Sclerosis, cardiovascular disease, Dementia, frontotemporal dementia |
| Interactions | AKT, ALS, AND, ASTROCYTE, ASTROCYTES, CHCHD10 |
| KG Connections | 187 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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