| Gene Symbol | PTEN |
| Chromosome | 10 |
| Function | is a critical tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway, playing essential roles in neuronal survival, synaptic plasticity, and cellular homeostasis[@pten2021]. |
| Molecular Weight | 47 kDa |
| Amino Acids | 403 aa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone |
| GeneCards | PTEN |
| Human Protein Atlas | PTEN |
| Phosphorylation | Ser380/Thr382/Thr383 phosphorylation inhibits PTEN activity and promotes stability |
| Oxidation | Reactive oxygen species can transiently inhibit PTEN |
| Ubiquitination | WWP2-mediated ubiquitination targets PTEN for degradation |
| Acetylation | p300/CBP-mediated acetylation reduces PTEN function |
| SUMOylation | Modulates PTEN localization and function |
| Associated Diseases | AD, ALI, ALS, AR-/NE- mCRPC, Aging |
| Known Drugs/Compounds | RAPAMYCIN, circRNA, dimethyl fumarate, quercetin, rapamycin, metformin |
| Interactions | PI3K, AKT, DDIT3, NBR1, EMD, MAPK8 |
| KG Connections | 2604 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |