| Gene Symbol | CHCHD2 |
| Full Name | Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 |
| Chromosome | 7p13 |
| Protein Family | Coiled-Coil-Helix-Coiled-Coil-Helix (CHCHD) domain proteins |
| Protein Type | Protein |
| Function | is a small mitochondrial protein that plays critical roles in mitochondrial function, cellular metabolism, and Parkinson's disease (PD) pathogenesis. |
| Primary Expression | dopaminergic neurons of the substantia nigra pars compacta, explaining the selective vulnerability of these neurons in PD |
| Subcellular Localization | the intermembrane space, where it plays important roles in mitochondrial function, particularly in response to oxidative |
| Molecular Weight | 26 kDa |
| Amino Acids | 182 aa |
| Pathways | Mitophagy |
| UniProt ID | Search UniProt |
| GeneCards | CHCHD2 |
| Human Protein Atlas | CHCHD2 |
| Coiled-coil helix domain | Mediates protein-protein interactions |
| Associated Diseases | ALS, Aging, Amyotrophic Lateral Sclerosis, Dementia, Kii ALS/PDC |
| Interactions | GPX4, LRRK2, SNCA, TDP43, FBXO7, JNK |
| KG Connections | 194 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |