gene 727 words KG: DBH
Contents

DBH Gene

🧬 Gene Info
Gene SymbolDBH
Chromosome9q34.2
Protein TypeGene
FunctionDBH catalyzes the oxidative hydroxylation of dopamine to produce norepinephrine.
Subcellular Localizationthe Golgi apparatus and secretory vesicles of noradrenergic and adrenergic neurons. DBH deficiency
Molecular Weight73 kDa
Amino Acids603 aa
GeneCardsDBH
Human Protein AtlasDBH
GeneDBH (chromosome 9q34.2)
Protein ClassCopper-containing monooxygenase
Protein Size603 amino acids
Primary LocalizationGolgi apparatus, secretory vesicles of noradrenergic neurons
Cofactor RequirementAscorbate (vitamin C), copper
Disease AssociationsDBH deficiency, orthostatic hypotension, ADHD, schizophrenia, PD
Associated DiseasesALS
InteractionsADRA1A, ADRA2A, ADRB1, AMPK, APP, ATG5
KG Connections61 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

Locus coeruleus degeneration gates whether cholinergic dysfu
Score: 0.62

Knowledge Graph (12 edges)

ADRA1A interacts_with DBH
ADRB1 interacts_with DBH
DBH interacts_with IL33
DBH interacts_with NRG1
DBH interacts_with ERBB4
DBH interacts_with IL1RL1
DBH associated_with ALS
DBH co_discussed DRD1
DBH regulates NEURONS
DBH causes STING

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