gene 757 words KG: ERBB4 2026-03-24
kind:genesection:genesstate:published
Contents

ERBB4 Gene

🧬 Gene Info
Gene SymbolERBB4
Chromosome2q34
Protein FamilyEGFR/ERBB family
Protein TypeReceptor
FunctionBinds neuregulin (NRG) ligands
Primary Expressiondopaminergic neurons - Neuregulin protection studies - May affect LRRK2 signaling - Neurotrophic factor connections - Gene variants
Molecular Weight~180 kDa (full-length)
Amino Acids1308
PathwaysPI3K, MAPK
UniProt IDQ15303
NCBI Gene ID2065
Ensembl IDENSG00000178668
GeneCardsERBB4
Human Protein AtlasERBB4
Gene NameErb-B2 Receptor Tyrosine Kinase 4
Associated DiseasesALS, Alzheimer
InteractionsGLUD1, NRG1, NLGN2, DISC1, Rb, NNMT
KG Connections128 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates
DOCK3 - Dedicator of Cytokinesis 3
gene · KG edge: activates

Knowledge Graph (12 edges)

ERBB4 contributes_to NRG1
ERBB4 inhibits GLUD1
ERBB4 inhibits NRG1
ERBB4 inhibits NLGN2
ERBB4 regulates FOXM1
ERBB4 regulates RB1
ERBB4 inhibits DISC1
ERBB4 regulates EGF
ERBB4 regulates EGFR
ERBB4 mediates NRG1