| Gene Symbol | ADRA1A |
| Chromosome | 8p21.2 [@zhang2020] |
| Protein Type | Gene |
| Function | is a gene encoding the alpha-1A adrenergic receptor (ADRA1A), a member of the G protein-coupled receptor (GPCR) superfamily. |
| Amino Acids | 466 aa |
| Exons | 6 |
| Pathways | MAPK Pathway |
| UniProt ID | P35348 |
| NCBI Gene ID | 148 |
| Ensembl ID | ENSG00000120907 |
| GeneCards | ADRA1A |
| Human Protein Atlas | ADRA1A |
| Extracellular Domain | Contains ligand-binding sites for catecholamines (epinephrine, norepinephrine) |
| Transmembrane Domains (7) | Form the receptor core and G protein coupling interface |
| Intracellular Loops | Interface with G proteins (primarily Gq/11) and β-arrestins |
| Associated Diseases | ALS |
| Interactions | ADRA1B, ADRA2A, ADRB1, DBH, DRD1, DRD2 |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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