| Gene Symbol | SLC1A2 |
| Full Name | Solute Carrier Family 1 Member 2 (EAAT2) |
| Aliases | EAAT2 |
| Chromosome | 11p13 |
| Protein Type | Gene |
| Function | encodes a protein of 574 amino acids with a molecular weight of approximately 66 kDa. |
| Primary Expression | astrocytes surrounding synapses, where it plays a critical role in synaptic homeostasis and neuroprotection |
| Molecular Weight | 66 kDa |
| Amino Acids | 574 aa |
| Exons | 19 |
| Pathways | Tdp-43, oxidative stress response, synaptic plasticity, unfolded protein response |
| GeneCards | SLC1A2 |
| Human Protein Atlas | SLC1A2 |
| Astrocytes | The primary cellular expression site, particularly perisynaptic astrocyte processes |
| Cerebral cortex | High expression in layers II-IV |
| Associated Diseases | ADHD, ALS, Alzheimer, Alzheimer's disease, anxiety |
| Interactions | AND, ANXIETY, APOE, App, AQP4, ASTROCYTE |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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