gene 622 words KG: YY1 2026-03-24
kind:genesection:genesstate:published
Contents

YY1 — Yin Yang 1

🧬 Gene Info
Gene SymbolYY1
Full NameYin Yang 1
Chromosome14q32.31
Protein TypeTranscription Factor
FunctionThe YY1 gene encodes Yin Yang 1, a ubiquitously expressed zinc-finger transcription factor.
Primary ExpressionUbiquitous, Brain, Muscle, Heart
PathwaysCgas-Sting, Mtor, Oxidative Phosphorylation
UniProt IDQ08050
NCBI Gene ID7528
Ensembl IDENSG00000100811
OMIM400713
GeneCardsYY1
Human Protein AtlasYY1
Associated DiseasesALS, Aging, Alzheimer, Ataxia, Dystonia
InteractionsUSP7, EGFR, SLC7A11, CX3CL1, CX3CR1, IRF1
KG Connections221 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
CCL5 — C-C Motif Chemokine Ligand 5
gene · KG edge: activates
BECN1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

YY1 associated_with HDAC2
YY1 associated_with LAMP1
YY1 associated_with ADNP
YY1 associated_with BECN1
YY1 associated_with SIRT1
YY1 associated_with LC3
YY1 interacts_with USP7
YY1 activates EGFR
YY1 inhibits SLC7A11
YY1 inhibits CX3CL1