gene 1,148 words KG: SLC1A2 2026-03-24
kind:genesection:genesstate:published
Contents

SLC1A2 — Solute Carrier Family 1 Member 2 (EAAT2)

🧬 Gene Info
Gene SymbolSLC1A2
Full NameSLC1A2 — Solute Carrier Family 1 Member 2 (EAAT2)
AliasesEAAT2
Chromosome11p13
Protein TypeGene
Functionencodes a protein of 574 amino acids with a molecular weight of approximately 66 kDa.
Primary Expressionastrocytes surrounding synapses, where it plays a critical role in synaptic homeostasis and neuroprotection
Molecular Weight66 kDa
Amino Acids574 aa
Exons19
PathwaysTdp-43, oxidative stress response, synaptic plasticity, unfolded protein response
NCBI Gene IDSearch NCBI
GeneCardsSLC1A2
Human Protein AtlasSLC1A2
Associated DiseasesADHD, ALS, ALZHEIMER'S DISEASE, Alzheimer, Fragile X Syndrome
InteractionsPROGRANULIN, AQP4, GRN, GJA1, APOE, TDP-43
KG Connections132 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (13)

Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto
Score: 0.45
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (6)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
Dementia Australia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates

Knowledge Graph (12 edges)

SLC1A2 regulates glutamate homeostasis
SLC1A2 protects_against excitotoxicity
SLC1A2 associated_with seizures
SLC1A2 implicated_in febrile seizures
SLC1A2 implicated_in Fragile X Syndrome
SLC1A2 associated_with ADHD
SLC1A2 contributes_to tau hyperphosphorylation
SLC1A2 associated_with anxiety
SLC1A2 activates PROGRANULIN
SLC1A2 activates AQP4