concept

BDNF SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BDNF SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

1Analyses

1Outgoing

44Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	BDNF SIGNALING

Pathway Diagram

graph TD
    BDNF_SIGNALING["BDNF SIGNALING"]
    TrkB["TrkB"] -->|"activates"| BDNF_SIGNALING
    PSD_95["PSD-95"] -->|"regulates"| BDNF_SIGNALING
    Elamipretide["Elamipretide"] -->|"activates"| BDNF_SIGNALING
    IL_6["IL-6"] -->|"inhibits"| BDNF_SIGNALING
    BDNF["BDNF"] -->|"activates"| BDNF_SIGNALING
    CREB["CREB"] -->|"activates"| BDNF_SIGNALING
    TNF["TNF"] -->|"inhibits"| BDNF_SIGNALING
    AMYLOID["AMYLOID"] -->|"activates"| BDNF_SIGNALING

Outgoing (1)

Target	Relation	Type	Str
Depression	contributes_to	disease	0.75

Incoming (44)

Source	Relation	Type	Str
TrkB	activates	protein	0.92
PSD-95	regulates	protein	0.90
PSD-95	associated_with	protein	0.90
Antidepressant Drugs	modulates	drug	0.85
MUTANT HUNTINGTIN	inhibits	protein	0.85
AAV-CYP46A1	upregulates	drug	0.85
SIRT1	enhances	gene	0.70
SIRT1 activation	enhances	phenotype	0.70
Elamipretide	activates	drug	0.70
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
TNF-Α	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
TNF-Α	inhibits	gene	0.60
IL-10	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
CREB	activates	gene	0.60
AMYLOID	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
IL-6	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
APP	inhibits	gene	0.60
TNF	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
WNT	activates	gene	0.60
BDNF	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
TNF	inhibits	gene	0.60
AND	activates	gene	0.60
Autism	activates	disease	0.55
Neurodegeneration	expressed_in	disease	0.55
Als	expressed_in	disease	0.55
Ms	expressed_in	disease	0.55
Alzheimer	therapeutic_target	disease	0.55
Neuroinflammation	inhibits	disease	0.55
Alzheimer	inhibits	disease	0.55
Inflammation	inhibits	disease	0.55
Ms	inhibits	disease	0.55
Als	inhibits	disease	0.55
Inflammation	therapeutic_target	disease	0.55
Neuroinflammation	therapeutic_target	disease	0.55
Ms	therapeutic_target	disease	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study demonstrates that exercise-conditioned plasma transfers cognitive bene

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning BDNF SIGNALING in their description or question text

No additional research found