gene 946 words KG: MAP2 2026-03-22
kind:genesection:genesstate:published
Contents

MAP2 Gene

🧬 Gene Info
Gene SymbolMAP2
Full NameMicrotubule Associated Protein 2
AliasesMicrotubule-Associated Protein 2
Protein TypeProtein
Functionis a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expressionneuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Subcellular Localizationdendrites. It plays critical roles in dendritic architecture, synaptic plasticity, microtubule stabilization, and intrac
Molecular Weight280 kDa
PathwaysApoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt IDSearch UniProt
GeneCardsMAP2
Human Protein AtlasMAP2
Associated DiseasesAD, ALI, ALS, AMI, Aging
Known Drugs/Compoundsrapamycin
InteractionsMAP1B, MAP6, ACTB, ATG7, ESR1, ESR2
KG Connections392 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (8)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Validation: Membrane-Nucleation in iPSC Neurons
validation · proposed · Score: 0.40
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
ATG7 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

MAP2 interacts_with MAP1B
MAP2 interacts_with MAP6
MAP2 associated_with SYN1
MAP2 associated_with CTSD
MAP2 associated_with MAP1LC3B
MAP2 associated_with SNAP25
MAP2 associated_with CTSB
MAP2 associated_with SYT1
MAP2 associated_with TFEB
MAP2 associated_with MTOR