gene 576 words KG: CD68 2026-03-24
kind:genesection:genesstate:published
Contents

CD68 Gene

🧬 Gene Info
Gene SymbolCD68
Full NameCluster of Differentiation 68
AliasesMacrosialin
Chromosome17p13.1
FunctionCD68 is a member of the lysosomal-associated membrane protein (LAMP) family:
Primary Expressionmonocytes and macrophages
Amino Acids22 aa
PathwaysGlial Phagocytosis
NCBI Gene ID968
Ensembl IDENSG00000129226
OMIM609453
GeneCardsCD68
Human Protein AtlasCD68
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Cancer
InteractionsMMP2, TNF, CD47, TLR4, MMP9, CGAS
KG Connections693 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (30)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62

Related Analyses (16)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (14)

Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - ALOX15 overexpression in healthy astrocytes should be
falsification · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
ANXA1 — Annexin A1
gene · KG edge: expressed_in
ALDH1L1
gene · KG edge: biomarker_for
AIF1 Gene
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

CD68 phosphorylates NRF2
CD68 phosphorylates TNF
CD68 phosphorylates NEUROINFLAMMATION
CD68 provides_data_for ds-f2c28aed24a7
CD68 biomarker_for MMP2
CD68 inhibits MMP2
CD68 associated_with CD14
CD68 associated_with CD163
CD68 biomarker_for MMP9
CD68 inhibits TNF