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general 2,389 words KG: GLUTAMATE
Contents

glutamate

🔬 Protein Info
Gene SymbolGLUTAMATE
Associated DiseasesCOGNITIVE DECLINE, EPILEPSY, EXCITOTOXICITY, FERROPTOSIS, GLUTAMATE EXCITOTOXICITY, GLYCOLYSIS
Known Drugs/CompoundsKETAMINE
InteractionsAKT, AMPK, APOE, APP, BIN1, PARKIN
KG Connections610 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (71)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Epigenetic Memory Erasure via TET2 Activation
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Purinergic Signaling Polarization Control
Score: 0.71TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Ganglioside Rebalancing Therapy
Score: 0.69Flotillin-1 Stabilization Compounds
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Complement C1q Subtype Switching
Score: 0.66Arginine Methylation Enhancement Therapy
Score: 0.65Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
pg 1/4Next →

Related Analyses (28)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (8)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (5)

acetylcholine
general · KG edge: co_discussedadra2b Gene
gene · KG edge: expressed_inGPX4 Gene - Glutathione Peroxidase 4
gene · KG edge: co_discussedAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

GLUTAMATE associated_with EXCITOTOXICITY
MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN

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