gene

SNAP25

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNAP25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

625Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SNAP25 gene page - synaptic vesicle protein, AD/PD/ALS

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🧬 Gene Info

Gene Symbol	SNAP
Full Name	25 (Synaptosomal-Associated Protein 25)
Aliases	SNAP25
Chromosome	20p12.2
Target Class	Structural Protein
Function	Snap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Mechanism of Action	Protein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation
Druggability	Low (0.33)
Clinical Stage	Approved
GeneCards	SNAP
Human Protein Atlas	SNAP
Lewy Body Dementia	Elevated CSF SNAP-25
Frontotemporal Dementia	Variable changes
Amyotrophic Lateral Sclerosis	May reflect motor neuron synaptic loss
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	RAPAMYCIN, rapamycin
Interactions	ACTB, STX11, ACTG1, SNCA, GAPDH, MAPK1
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Synaptic Vesicle Tau Capture Inhibition
KG Connections	625 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: SNAP25 — PDB 1KIL Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SNAP25["SNAP25"] -->|"regulates"| Synaptic_Vesicle_Tau_Capture_I["Synaptic Vesicle Tau Capture Inhibition"]
    SNAP25["SNAP25"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SNAP25["SNAP25"] -->|"activates"| Alzheimer["Alzheimer"]
    SNAP25["SNAP25"] -->|"activates"| Ms["Ms"]
    SNAP25["SNAP25"] -->|"activates"| Ischemia["Ischemia"]
    SNAP25["SNAP25"] -->|"activates"| Inflammation["Inflammation"]
    h_73e29e3a["h-73e29e3a"] -->|"therapeutic target"| SNAP25["SNAP25"]
    STX11["STX11"] -->|"interacts"| SNAP25["SNAP25"]
    ACTB["ACTB"] -->|"activates"| SNAP25["SNAP25"]
    LAMP1["LAMP1"] -->|"associated"| SNAP25["SNAP25"]
    style SNAP25 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (349)

Target	Relation	Type	Str
Fibroblast Activation	inhibits	process	0.90
Synaptic Dysfunction	biomarker_for	mechanism	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Schizophrenia	biomarker_for	disease	0.85
Synaptic function	involved_in	process	0.80
autophagy pathway	participates_in	pathway	0.80
Synaptic Vesicle Tau Capture Inhibition	regulates	mechanism	0.70
TAU	causes	protein	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	stabilizes	disease	0.70
ALS	treats	disease	0.70
TAU	associated_with	gene	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Fibrosis	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Epilepsy	activates	disease	0.65
Als	activates	disease	0.65
Als	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	regulates	disease	0.65
Depression	regulates	disease	0.65
Depression	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Prion	therapeutic_target	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Depression	interacts_with	disease	0.65
Depression	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65

Incoming (276)

Source	Relation	Type	Str
STX11	interacts_with	gene	0.90
h-73e29e3a	targets_gene	hypothesis	0.90
SV2A	interacts_with	protein	0.85
h-73e29e3a	targets	hypothesis	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.74
TAU	interacts_with	protein	0.70
TAU	destabilizes	protein	0.70
TAU	inhibits	protein	0.70
TAU	activates	protein	0.70
TAU	phosphorylates	protein	0.70
TAU	treats	protein	0.70
AMPK	activates	gene	0.70
TAU PHOSPHORYLATION	activates	phenotype	0.70
PI3K	activates	gene	0.65
TAU	regulates	protein	0.65
AMYLOID	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
RAPAMYCIN	activates	drug	0.65
PVALB	co_mentioned_with	gene	0.60
ACTB	activates	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ATG7	activates	gene	0.60
JUN	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
MAP2	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
P62	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
AKT	activates	gene	0.60
BLM	activates	gene	0.60
ATG7	co_discussed	gene	0.60
CTSB	co_discussed	gene	0.60
CTSD	co_discussed	gene	0.60
LAMP1	co_discussed	gene	0.60
MAP1LC3B	co_discussed	gene	0.60
MTOR	co_discussed	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synaptic Vesicle Tau Capture Inhibition	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217]	Chang CH, Lin CH, Lane HY	Int J Mol Sci	2021	1
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641]	Zhang X, Wei M, Fan J, Yan W, Zha X, Son	Autophagy	2021	1
Reference proteins to improve Core 1 and Core 2 Alzheimer's disease CSF and plas [PMID:41051312]	Karlsson L, Janelidze S, Barthélemy NR,	Brain	2026	0
Biomarkers of synaptic degeneration in Alzheimer's disease. [PMID:39701184]	Cheng Q, Fan Y, Zhang P, Liu H, Han J, Y	Ageing research reviews	2025	0
Common Mechanism Underlying Synaptic Dysfunction Caused by Preformed Fibril-Indu [PMID:41027737]	["Dimitrov D", "Raja S", "Noor H", "Taka	The Journal of neuroscience :	2025	0
Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzh [PMID:40993829]	Nussbaumer J, Barve A, Zufferey V, Espou	Translational neurodegeneratio	2025	0
SNAP25 variant I67N: synaptic phenotypes, drug response and proteome changes in [PMID:40181518]	Østergaard M, Barbagallo P, Frederiksen	Brain : a journal of neurology	2025	0
Microglia mediate memory dysfunction via excitatory synaptic elimination in a fr [PMID:39285282]	["Li S", "Liu H", "Lv P", "Yao Y", "Peng	Journal of neuroinflammation	2024	0
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolati [PMID:37992714]	["Guo B", "Xi K", "Mao H", "Ren K", "Xia	Neuron	2024	0
Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567]	["Porzuczek J"]	Sensors (Basel, Switzerland)	2024	0
Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum [PMID:38325331]	Nilsson J, Pichet Binette A, Palmqvist S	Brain	2024	0
The Relationship between SNAP25 and Some Common Human Neurological Syndromes. [PMID:38963116]	Shu J, Peng F, Li J, Liu Y, Li X et al.	Curr Pharm Des	2024	0
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J, Li	Frontiers in immunology	2024	0
A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012]	["Azimjonov J", "\u00d6zmen A", "Varan M	Multimedia tools and applicati	2023	0
Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesic [PMID:37343100]	Papantoniou C, Laugks U, Betzin J, Capit	Science advances	2023	0
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CR [PMID:36839332]	Zhang Y, Zhou Q, Lu L, Su Y, Shi W, Zhan	Nutrients	2023	0
Disorders of synaptic vesicle fusion machinery. [PMID:32916768]	Melland H, Arvell EH, Gordon SL	J Neurochem	2021	0
Cysteine string proteins. [PMID:32044380]	Gundersen CB	Prog Neurobiol	2020	0
Sex Differences in Frail Older Adults with Foot Pain in a Spanish Population: An [PMID:32847063]	["Navarro-Flores E", "Romero-Morales C",	International journal of envir	2020	0
Genome-wide meta-analysis of depression identifies 102 independent variants and [PMID:30718901]	["Howard D", "Adams M", "Clarke T", "Haf	Nature neuroscience	2019	0

SNAP25

Understanding Entity Pages

Summary

Wiki Pages (21)

SNAP-25 - Synaptic Biomarker

Epigenetic Alterations in Alzheimer's Disease

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

RNA Metabolism Dysregulation in Alzheimer's Disease

Synaptic Dysfunction in Neurodegeneration

Allen Human Brain Atlas

PTBP2 - Polypyrimidine Tract Binding Protein 2

SETD1B

ALS Regional Onset and Spread: Network-Level Staging Model

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

Synaptic Vesicle Cycle

Proteome Atlas for Neurodegenerative Diseases

Proteome Atlas for Neurodegenerative Diseases

Epigenetic Alterations in Alzheimer's Disease

Synaptic Dysfunction Comparison in Neurodegenerative Diseases

synaptic-vesicle-cycling-neurodegeneration

SYT5 Gene

PRRT2 Gene

SLC18A2 Gene

Tau Immunotherapy