gene 2,031 words KG: FLNC
Contents

FLNC Gene

🧬 Gene Info
Gene SymbolFLNC
AliasesFilamin C
Chromosome7q32.1
Functionis a large actin-binding protein that plays essential roles in maintaining the structural integrity of skeletal and cardiac muscle.
Primary Expressionskeletal and cardiac muscle, with lower levels detected in some other tissues
Molecular Weight291 kDa
Amino Acids632 aa
Exons48
Pathwaysubiquitin-proteasome
Ensembl IDENSG00000128591
GeneCardsFLNC
Human Protein AtlasFLNC
Skeletal MuscleVery high expression in all major skeletal muscle groups, concentrated at the Z-disc and myotendinous junctions.
Cardiac MuscleHigh expression in both ventricular and atrial myocardium, particularly in the left ventricle.
Smooth MuscleLow expression in some smooth muscle populations.
Associated DiseasesMyofibrillar Myopathy
InteractionsGENES, MYOT, NBR1, P62, WAS
KG Connections46 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Knowledge Graph (12 edges)

FLNC causes Myofibrillar Myopathy
BRCA1 degrades FLNC
DES degrades FLNC
DNAJB6 degrades FLNC
FLNC degrades MYOT
FLNC degrades NBR1
FLNC degrades P62
FLNC degrades SQSTM1
BRCA1 co_discussed FLNC
DES co_discussed FLNC

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