gene

MYOT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYOT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

1Analyses

50Outgoing

26Incoming

Summary

Comprehensive analysis of MYOT gene encoding myotilin protein in myofibrillar myopathy, inclusion body myositis, and related neuromuscular disorders with implications for neurodegenerative disease research

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🧬 Gene Info

Gene Symbol	MYOT
Chromosome	19q13.33
Function	is a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight	57 kDa
Amino Acids	493 aa
Exons	13
Pathways	ubiquitin-proteasome
Ensembl ID	ENSG00000136244
GeneCards	MYOT
Human Protein Atlas	MYOT
Associated Diseases	Myofibrillar Myopathy
Interactions	NBR1, P62, BRCA1, DES, DNAJB6, FLNC
KG Connections	150 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MYOT["<b>MYOT</b>"]
    Myofibrillar_Myopathy{"Myofibrillar Myopathy"}
    MYOT -->|"causes"| Myofibrillar_Myopathy
    myofibrillar_myopathy{"myofibrillar myopathy"}
    MYOT -->|"causes"| myofibrillar_myopathy
    NBR1["NBR1"]
    MYOT -->|"degrades"| NBR1
    P62["P62"]
    MYOT -->|"degrades"| P62
    SQSTM1["SQSTM1"]
    MYOT -->|"degrades"| SQSTM1
    BRCA1["BRCA1"]
    BRCA1 -->|"degrades"| MYOT
    DES["DES"]
    DES -->|"degrades"| MYOT
    DNAJB6["DNAJB6"]
    DNAJB6 -->|"degrades"| MYOT
    FLNC["FLNC"]
    FLNC -->|"degrades"| MYOT
    style MYOT fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (124)

Target	Relation	Type	Str
Myofibrillar Myopathy	causes	disease	0.95
myofibrillar myopathy	causes	disease	0.70
NBR1	degrades	entity	0.60
P62	degrades	entity	0.60
SQSTM1	degrades	entity	0.60
P62	associated_with	gene	0.60
DES	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
FLNC	associated_with	gene	0.60
DNAJB6	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
AND	associated_with	gene	0.60
TTN	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Proteasome	associated_with	pathway	0.60
GENES	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Ca1	expressed_in	brain_region	0.55
NBR1	activates	gene	0.50
P62	activates	protein	0.50
NBR1	associated_with	gene	0.50
P62/SQSTM1	associated_with	protein	0.50
Proteins	associated_with	protein	0.50
CHMP2B	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
MTOR	co_discussed	pathway	0.40
PINK1	co_discussed	gene	0.40
PTEN	co_discussed	gene	0.40
SPHK1	co_discussed	gene	0.40
TBK1	co_discussed	gene	0.40
TFEB	co_discussed	protein	0.40
VCP	co_discussed	gene	0.40
VALOSIN	co_discussed	gene	0.40
AMBRA1	co_discussed	protein	0.40
UBIQUITIN	co_discussed	protein	0.40
ATM	co_discussed	protein	0.40
BCL2	co_discussed	gene	0.40
BCL2L11	co_discussed	gene	0.40
BCL2L13	co_discussed	gene	0.40
BECN1	co_discussed	gene	0.40
BNIP3	co_discussed	gene	0.40
BNIP3L	co_discussed	protein	0.40
CALCOCO2	co_discussed	gene	0.40
NDP52	co_discussed	gene	0.40
CANX	co_discussed	gene	0.40
CAT	co_discussed	gene	0.40
CTSD	co_discussed	gene	0.40
HEPSIN	co_discussed	protein	0.40
DDIT3	co_discussed	gene	0.40
CHOP	co_discussed	gene	0.40

Incoming (26)

Source	Relation	Type	Str
BRCA1	degrades	entity	0.60
DES	degrades	entity	0.60
DNAJB6	degrades	entity	0.60
FLNC	degrades	entity	0.60
DNAJB6	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
FLNC	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
DES	associated_with	gene	0.60
P62	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
BRCA1	activates	protein	0.50
DES	activates	gene	0.50
DNAJB6	activates	gene	0.50
FLNC	activates	gene	0.50
AUTOPHAGY	activates	gene	0.50
GENES	activates	gene	0.50
P62/SQSTM1	activates	protein	0.50
RELA	co_discussed	gene	0.40
ABCD3	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
NEURON	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
ALZHEIMER DISEASE	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MYOT

Understanding Entity Pages

Summary

Wiki Pages (9)

MYOT Gene

FLNC Gene

ATG9A Gene

Parabrachial Nucleus (PBN) Neurons

Paramedian Lobule Neurons

Simplex Lobule Neurons

Spinal Cord Interneurons in Motor Neuron Disease

CCDC88A — Coiled-Coil Domain Containing 88A