protein

WAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

249Connections

0Hypotheses

15Analyses

48Outgoing

50Incoming

Summary

Wiskott-Aldrich Syndrome protein - regulates actin cytoskeleton, linked to neurodegeneration

View on Wiki →

🔬 Protein Info

Gene Symbol	WAS
Aliases	Wiskott-Aldrich Syndrome protein
Function	WASp exists in an autoinhibited conformation where the VCA domain is masked[@symons1996].
Molecular Weight	52 kDa
GeneCards	WAS
Human Protein Atlas	WAS
Interactions	TAU, TBK1, TREM2, IL18, LAMP2, SNCA
KG Connections	249 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WAS["<b>WAS</b>"]
    TAU(["TAU"])
    WAS -.->|"inhibits"| TAU
    TBK1(["TBK1"])
    WAS -->|"activates"| TBK1
    TREM2(["TREM2"])
    WAS -->|"interacts_with"| TREM2
    IL18(["IL18"])
    WAS -->|"activates"| IL18
    LAMP2(["LAMP2"])
    WAS -->|"activates"| LAMP2
    SNCA(["SNCA"])
    WAS -->|"activates"| SNCA
    CRH(["CRH"])
    CRH -->|"activates"| WAS
    POMC(["POMC"])
    POMC -->|"activates"| WAS
    STING(["STING"])
    STING -->|"co_discussed"| WAS
    C1Q(["C1Q"])
    C1Q -->|"co_discussed"| WAS
    style WAS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (48)

Target	Relation	Type	Str
TAU	inhibits	protein	0.50
TBK1	activates	gene	0.50
TREM2	interacts_with	gene	0.50
IL18	activates	gene	0.50
LAMP2	activates	protein	0.50
SNCA	activates	gene	0.50
TNF	activates	gene	0.50
AUTOPHAGY	inhibits	gene	0.50
PVALB	inhibits	gene	0.50
PKA	activates	protein	0.50
TNF	expressed_in	gene	0.50
TGM2	activates	gene	0.50
TREM2	activates	gene	0.50
NEURON	inhibits	gene	0.50
SNCA	expressed_in	gene	0.50
TRPV4	expressed_in	gene	0.50
APP	regulates	gene	0.50
IL-10	activates	protein	0.50
IL-1Β	activates	protein	0.50
NLRP3	expressed_in	protein	0.50
NLRP6	expressed_in	gene	0.50
PYCARD	regulates	gene	0.50
PKM2	interacts_with	protein	0.50
CHMP4B	activates	gene	0.50
GBM	activates	gene	0.50
GPX4	activates	gene	0.50
KIF4A	activates	gene	0.50
NDP52	activates	gene	0.50
OPTN	activates	gene	0.50
P62	activates	protein	0.50
PARKIN	activates	gene	0.50
PINK1	activates	gene	0.50
RAGE	activates	gene	0.50
CANCER	regulates	gene	0.50
SIRT2	activates	gene	0.50
CASPASE-1	causes	protein	0.50
NLRP3	causes	protein	0.50
NTRK2	activates	gene	0.50
SCN4B	activates	gene	0.50
SLC17A7	activates	protein	0.50
UNC5C	activates	gene	0.50
TAZ	activates	gene	0.50
CAV2	inhibits	gene	0.50
CAV2.3	inhibits	protein	0.50
ATP	phosphorylates	protein	0.50
FASN	activates	gene	0.50
HMGCR	activates	gene	0.50
SCD1	activates	gene	0.50

Incoming (201)

Source	Relation	Type	Str
CRH	activates	gene	0.50
POMC	activates	gene	0.50
STING	co_discussed	gene	0.50
C1Q	co_discussed	gene	0.50
CASPASE-1	co_discussed	protein	0.50
IL-18	co_discussed	protein	0.50
IL-1Β	co_discussed	protein	0.50
NLRP3	co_discussed	protein	0.50
AMYLOID	regulates	gene	0.50
PRESENILIN	regulates	protein	0.50
RNA	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
CD19	co_discussed	gene	0.50
ALZHEIMER	interacts_with	gene	0.50
EPILEPSY	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
ALZHEIMER	co_discussed	gene	0.50
LRP6	co_discussed	gene	0.50
WNT3A	inhibits	gene	0.50
NEURON	activates	gene	0.50
RIG-I	activates	protein	0.50
ALZHEIMER	expressed_in	gene	0.50
RNA	expressed_in	gene	0.50
STAT3	co_discussed	gene	0.50
TNF	co_discussed	gene	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
TAU	activates	protein	0.50
EPHA2	activates	gene	0.50
FLOT1	activates	gene	0.50
CANCER	inhibits	gene	0.50
TP53	inhibits	gene	0.50
NLRP3	activates	protein	0.50
CLUSTERIN	co_discussed	protein	0.50
GENES	co_discussed	gene	0.50
ACSL4	co_discussed	gene	0.50
GPX4	co_discussed	gene	0.50
HO-1	co_discussed	protein	0.50
NRF2	co_discussed	gene	0.50
SLC7A1	co_discussed	gene	0.50
SLC7A11	co_discussed	gene	0.50
PARKINSON	inhibits	gene	0.50
PARKIN	co_discussed	gene	0.50
PP2A	inhibits	gene	0.50
GAA	interacts_with	gene	0.50
NF-ΚB	activates	gene	0.50
RNA	activates	gene	0.50
PARKINSON	activates	gene	0.50
FSP1	co_discussed	gene	0.50
KCNK2	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (15)

Scientific analyses that reference this entity

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

What specific gene expression signatures in aging mouse brain predict human AD v

neurodegeneration | 2026-04-12 | 0 hypotheses

What specific gene expression signatures in aging mouse white matter predict hum

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

WAS

Understanding Entity Pages

Summary

Wiki Pages (21)

AlphaFold3 (Google DeepMind / Isomorphic Labs)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Pathway Diagram

Outgoing (48)

Incoming (201)

Targeting Hypotheses (0)

Mentioning Analyses (15)

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What is the temporal sequence of TREM2 signaling transition from protective to i

What specific gene expression signatures in aging mouse brain predict human AD v

What specific gene expression signatures in aging mouse white matter predict hum

Which specific cell types show greatest vulnerability in AD based on SEA-AD tran

Can pathological vs physiological C1q tagging be distinguished at the molecular

Does structural 'normalization' of APOE4 domain interactions actually improve am

Which specific post-translational modifications create druggable epitopes unique

Which specific post-translational modifications distinguish pathological from ph

Do tau-specific HSP90 conformational states exist that differ from other client

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

What is the optimal therapeutic window during preclinical AD for epigenetic repr

Do microglia actually switch between glycolytic and oxidative phosphorylation as

What determines the optimal timing and dosing of ketogenic interventions for neu

Related Papers (0)

WAS

Understanding Entity Pages

Summary

Wiki Pages (21)

AlphaFold3 (Google DeepMind / Isomorphic Labs)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nimodipine-als

CBS/PSP Treatment Rankings

Frontotemporal Dementia (FTD)

coq10-neurodegeneration

williams-syndrome

Pathway Diagram

Outgoing (48)

Incoming (201)

Targeting Hypotheses (0)

Mentioning Analyses (15)

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What is the temporal sequence of TREM2 signaling transition from protective to i

What specific gene expression signatures in aging mouse brain predict human AD v

What specific gene expression signatures in aging mouse white matter predict hum

Which specific cell types show greatest vulnerability in AD based on SEA-AD tran

Can pathological vs physiological C1q tagging be distinguished at the molecular

Does structural 'normalization' of APOE4 domain interactions actually improve am

Which specific post-translational modifications create druggable epitopes unique

Which specific post-translational modifications distinguish pathological from ph

Do tau-specific HSP90 conformational states exist that differ from other client

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

What is the optimal therapeutic window during preclinical AD for epigenetic repr

Do microglia actually switch between glycolytic and oxidative phosphorylation as

What determines the optimal timing and dosing of ketogenic interventions for neu

Related Papers (0)