| Gene Symbol | BRD4 |
| Full Name | Bromodomain-Containing Protein 4 |
| Chromosome | 19p13.12 |
| Target Class | Epigenetic Regulator |
| Function | encodes a member of the bromodomain and extra-terminal domain (BET) protein family that functions as an epigenetic reader of acetylated histones and a master regulator of transcriptional elongation. |
| Mechanism of Action | BRD4 inhibition reduces neuroinflammatory super-enhancer activity while biased BRD4 modulators can selectively restore neuroprotective gene expression |
| Druggability | Low (0.40) |
| Clinical Stage | Phase II |
| Pathways | NF-κB |
| UniProt ID | [O60885](https://www.uniprot.org/uniprot/O60885) |
| Ensembl ID | ENSG00000141867 |
| GeneCards | BRD4 |
| Human Protein Atlas | BRD4 |
| Inflammatory gene activation | BRD4 is recruited to NF-κB-responsive promoters during inflammation, serving as a co-activator for pro-inflammatory transcription |
| Bookmarking during mitosis | BRD4 remains bound to acetylated chromatin during mitosis, "bookmarking" active genes for rapid reactivation after cell division |
| Associated Diseases | ALS, INFLAMMATION, Lymphoma, memory consolidation, multiple sclerosis, neurodegeneration |
| Known Drugs/Compounds | JQ1 |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, APOPTOSIS |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Chromatin Accessibility Restoration via BRD4 Modul BET Bromodomain Inhibition for Neuroinflammation S Convergent NF-κB enhancers across diverse priming (+1 more) |
| KG Connections | 401 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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