gene 1,007 words KG: VDAC1 2026-03-24
kind:genesection:genesstate:published
Contents

VDAC1 — Voltage Dependent Anion Channel 1

🧬 Gene Info
Gene SymbolVDAC1
Full NameVoltage Dependent Anion Channel 1
Chromosome5q31
Protein TypeChannel
FunctionVDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary ExpressionBrain, Heart, Liver, Kidney
Molecular Weight31 kDa
PathwaysApoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt IDP21796
NCBI Gene ID7416
Ensembl IDENSG00000110833
GeneCardsVDAC1
Human Protein AtlasVDAC1
Symbol [@thinnes2014] VDAC1 [@giorgio2018] Full NameVoltage Dependent Anion Channel 1
Associated DiseasesALS, ALZHEIMER, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer
InteractionsDRP1, DNM1L, OPA1, AKT, TBK1, MCU
KG Connections507 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (4)

Live-cell microscopy of mitochondria-lysosome contacts and c
exploratory · proposed · Score: 0.90
MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40
s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: debate_co_mention
BNIP3 Gene
gene · KG edge: inhibits
BAX Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

VDAC1 activates DRP1
VDAC1 activates DNM1L
VDAC1 activates OPA1
VDAC1 activates AKT
VDAC1 activates TBK1
VDAC1 regulates PARKIN
VDAC1 activates MCU
VDAC1 associated_with PINK1
VDAC1 expressed_in HSPA9
VDAC1 expressed_in CYCS