| Gene Symbol | SPHK1 |
| Full Name | Sphingosine Kinase 1 |
| Chromosome | 17q25.1 |
| Protein Type | Kinase |
| Function | ### Sphingolipid Rheostat |
| Primary Expression | Hippocampus, Cortex, Cerebellum, White matter (widespread) |
| Molecular Weight | 42.5 kDa |
| Exons | 6 |
| Pathways | NF-κB |
| UniProt ID | Q9NYA1 |
| NCBI Gene ID | 8877 |
| Ensembl ID | ENSG00000176884 |
| OMIM | 603730 |
| GeneCards | SPHK1 |
| Human Protein Atlas | SPHK1 |
| Associated Diseases | Als, Atherosclerosis, Cardiac, Cardiovascular, Fibrosis, Heart Failure |
| Known Drugs/Compounds | rapamycin |
| Interactions | Actin, ALS, ALS-CAUSING MUTATIONS, ASTROCYTE, ASTROCYTES, ATG |
| SciDEX Hypotheses | Ceramide-Sphingosine-1-Phosphate Axis Rebalancing |
| KG Connections | 211 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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