protein 1,654 words KG: VALOSIN 2026-03-27
kind:proteinsection:proteinstopic:alstopic:ftdtopic:ibmpfdtopic:protein-quality-control
Contents

VCP (Valosin-Containing Protein)

🔬 Protein Info
Gene SymbolVCP
AliasesValosin-Containing Protein
Chromosome9p13.3
Functionof 806 amino acids with a molecular weight of approximately 97 kDa[@kobayashi2000]
Molecular Weight97 kDa
Amino Acids806 aa
Exons17
PathwaysEr Stress
GeneCardsVCP
Human Protein AtlasVCP
CofactorFunction
UFD1-NPL4Substrate recognition
p47Membrane fusion
UBXD1/UBXD8Ubiquitin chain binding
Ataxin-3Deubiquitination
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Ms
InteractionsLC3, TBK1, PTEN, SPHK1, PINK1, TARDBP
KG Connections214 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

VCP-Mediated Autophagy Enhancement
Score: 0.41
APOE-Dependent Autophagy Restoration
Score: 0.61
Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Stress Granule Phase Separation Modulators
Score: 0.49

Related Analyses (7)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic
validation · proposed · Score: 0.40
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40
Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40

See Also (9)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
CHMP2B — Charged Multivesicular Body Protein 2B
gene · KG edge: activates
BECN1 Gene
gene · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

VALOSIN associated_with VCP
VALOSIN regulates JUN
VALOSIN associated_with G3BP1
VALOSIN activates LC3
VALOSIN activates TBK1
VALOSIN expressed_in NLRP3
VALOSIN associated_with UBIQUITIN
VALOSIN activates PTEN
VALOSIN activates SPHK1
VALOSIN activates PINK1