gene 2,588 words KG: ABCA7
Contents

ABCA7 (ATP-Binding Cassette Transporter A7)

🧬 Gene Info
Gene SymbolABCA7
FunctionABCA7 encodes ATP-binding cassette transporter A7, a member of the ABC transporter family.
Primary Expressionimmune cells and the brain, where it plays important roles in lipid transport and cellular homeostasis
PathwaysCholesterol, Glycolysis, Immune Response, Lipid Metabolism, Nf-Κb
Ensembl IDENSG00000064687
GeneCardsABCA7
Human Protein AtlasABCA7
Lipid effluxMediates transport of lipids to apolipoproteins
Phospholipid transportTransfers phospholipids across cellular membranes
Cholesterol homeostasisRegulates cellular cholesterol levels
Immune functionModulates macrophage and microglial responses
PhagocytosisInvolved in cellular clearance mechanisms
Associated DiseasesALZHEIMER'S DISEASE, Als, Alzheimer, Atherosclerosis
InteractionsNPY, CASS4, EPHA1, CLU, BIN1, CD33
KG Connections591 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (22)

Membrane Cholesterol Gradient Modulators
Score: 0.52
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (4)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ABCA7 associated_with APOE
ABCA7 associated_with TREM2
ABCA7 associated_with APP
ABCA7 associated_with ATP13A2
ABCA7 associated_with BIN1
ABCA7 associated_with C9ORF72
ABCA7 associated_with CD33
ABCA7 associated_with CLU
ABCA7 associated_with FUS
ABCA7 associated_with GBA